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Increased DNA methylation variability in type 1 diabetes across three immune effector cell types.
Paul, Dirk S; Teschendorff, Andrew E; Dang, Mary A N; Lowe, Robert; Hawa, Mohammed I; Ecker, Simone; Beyan, Huriya; Cunningham, Stephanie; Fouts, Alexandra R; Ramelius, Anita; Burden, Frances; Farrow, Samantha; Rowlston, Sophia; Rehnstrom, Karola; Frontini, Mattia; Downes, Kate; Busche, Stephan; Cheung, Warren A; Ge, Bing; Simon, Marie-Michelle; Bujold, David; Kwan, Tony; Bourque, Guillaume; Datta, Avik; Lowy, Ernesto; Clarke, Laura; Flicek, Paul; Libertini, Emanuele; Heath, Simon; Gut, Marta; Gut, Ivo G; Ouwehand, Willem H; Pastinen, Tomi; Soranzo, Nicole; Hofer, Sabine E; Karges, Beate; Meissner, Thomas; Boehm, Bernhard O; Cilio, Corrado; Elding Larsson, Helena; Lernmark, Åke; Steck, Andrea K; Rakyan, Vardhman K; Beck, Stephan; Leslie, R David.
Affiliation
  • Paul DS; Medical Genomics, UCL Cancer Institute, University College London, London WC1E 6BT, UK.
  • Teschendorff AE; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK.
  • Dang MA; CAS Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  • Lowe R; Statistical Cancer Genomics, UCL Cancer Institute, University College London, London WC1E 6BT, UK.
  • Hawa MI; The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
  • Ecker S; The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
  • Beyan H; The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
  • Cunningham S; Medical Genomics, UCL Cancer Institute, University College London, London WC1E 6BT, UK.
  • Fouts AR; The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
  • Ramelius A; The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK.
  • Burden F; Barbara Davis Center for Childhood Diabetes, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.
  • Farrow S; Department of Clinical Sciences, Lund University, Skåne University Hospital, SE-20502 Malmö, Sweden.
  • Rowlston S; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.
  • Rehnstrom K; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.
  • Frontini M; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.
  • Downes K; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.
  • Busche S; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.
  • Cheung WA; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.
  • Ge B; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.
  • Simon MM; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.
  • Bujold D; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.
  • Kwan T; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.
  • Bourque G; British Heart Foundation Centre of Excellence, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
  • Datta A; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.
  • Lowy E; National Health Service Blood and Transplant, Cambridge Biomedical Campus, Cambridge CB2 0PT, UK.
  • Clarke L; Department of Human Genetics, McGill University, Montreal, Québec, Canada H3A 0G1.
  • Flicek P; McGill University and Genome Quebec Innovation Centre, Montreal, Québec, Canada H3A 0G1.
  • Libertini E; Department of Human Genetics, McGill University, Montreal, Québec, Canada H3A 0G1.
  • Heath S; McGill University and Genome Quebec Innovation Centre, Montreal, Québec, Canada H3A 0G1.
  • Gut M; Department of Human Genetics, McGill University, Montreal, Québec, Canada H3A 0G1.
  • Gut IG; McGill University and Genome Quebec Innovation Centre, Montreal, Québec, Canada H3A 0G1.
  • Ouwehand WH; Department of Human Genetics, McGill University, Montreal, Québec, Canada H3A 0G1.
  • Pastinen T; McGill University and Genome Quebec Innovation Centre, Montreal, Québec, Canada H3A 0G1.
  • Soranzo N; Department of Human Genetics, McGill University, Montreal, Québec, Canada H3A 0G1.
  • Hofer SE; McGill University and Genome Quebec Innovation Centre, Montreal, Québec, Canada H3A 0G1.
  • Karges B; Department of Human Genetics, McGill University, Montreal, Québec, Canada H3A 0G1.
  • Meissner T; McGill University and Genome Quebec Innovation Centre, Montreal, Québec, Canada H3A 0G1.
  • Boehm BO; Department of Human Genetics, McGill University, Montreal, Québec, Canada H3A 0G1.
  • Cilio C; McGill University and Genome Quebec Innovation Centre, Montreal, Québec, Canada H3A 0G1.
  • Elding Larsson H; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Lernmark Å; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Steck AK; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Rakyan VK; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Beck S; Medical Genomics, UCL Cancer Institute, University College London, London WC1E 6BT, UK.
  • Leslie RD; CNAG-CRG, Centre for Genomic Regulation, Barcelona Institute of Science and Technology (BIST), Baldiri Reixac 4, 08028 Barcelona, Spain.
Nat Commun ; 7: 13555, 2016 11 29.
Article in En | MEDLINE | ID: mdl-27898055
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Methylation / Diabetes Mellitus, Type 1 Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2016 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Methylation / Diabetes Mellitus, Type 1 Limits: Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2016 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom