KCTD2, an adaptor of Cullin3 E3 ubiquitin ligase, suppresses gliomagenesis by destabilizing c-Myc.

Kim, Eun-Jung; Kim, Sung-Hak; Jin, Xiong; Jin, Xun; Kim, Hyunggee

Kim, Eun-Jung; Kim, Sung-Hak; Jin, Xiong; Jin, Xun; Kim, Hyunggee.

Affiliation

Kim EJ; Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.
Kim SH; Institute of Animal Molecular Biotechnology, Korea University, Seoul, Republic of Korea.
Jin X; Department of Animal Science, College of Agriculture and Life Sciences, Chonnam National University, Gwangju, Republic of Korea.
Jin X; Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea.
Kim H; Institute of Animal Molecular Biotechnology, Korea University, Seoul, Republic of Korea.

Cell Death Differ ; 24(4): 649-659, 2017 04.

Article in En | MEDLINE | ID: mdl-28060381

Subject(s)

Adaptor Proteins, Signal Transducing/metabolism; Brain Neoplasms/pathology; Cullin Proteins/metabolism; Glioma/pathology; Potassium Channels/metabolism; Proto-Oncogene Proteins c-myc/metabolism; Adaptor Proteins, Signal Transducing/antagonists & inhibitors; Adaptor Proteins, Signal Transducing/genetics; Animals; Astrocytes/cytology; Astrocytes/metabolism; Brain Neoplasms/metabolism; Brain Neoplasms/mortality; Cell Line; Cullin Proteins/antagonists & inhibitors; Cullin Proteins/genetics; Cyclin-Dependent Kinase Inhibitor p16/deficiency; Cyclin-Dependent Kinase Inhibitor p16/genetics; Glioma/metabolism; Glioma/mortality; HEK293 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Nude; Neoplastic Stem Cells/cytology; Neoplastic Stem Cells/metabolism; Potassium Channels/chemistry; Potassium Channels/genetics; Protein Binding; Proto-Oncogene Proteins c-myc/antagonists & inhibitors; Proto-Oncogene Proteins c-myc/genetics; Signal Transduction; Ubiquitination

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Potassium Channels / Proto-Oncogene Proteins c-myc / Cullin Proteins / Adaptor Proteins, Signal Transducing / Glioma Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cell Death Differ Year: 2017 Document type: Article Country of publication: United kingdom

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