Xanthine Oxidase Induces Foam Cell Formation through LOX-1 and NLRP3 Activation.

Dai, Yao; Cao, Yongxiang; Zhang, Zhigao; Vallurupalli, Srikanth; Mehta, Jawahar L

Dai, Yao; Cao, Yongxiang; Zhang, Zhigao; Vallurupalli, Srikanth; Mehta, Jawahar L.

Affiliation

Dai Y; Department of Medicine, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA. daiyaoh@163.com.
Cao Y; Department of Internal Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China, 230022. daiyaoh@163.com.
Zhang Z; Department of Internal Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China, 230022.
Vallurupalli S; Department of Internal Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China, 230022.
Mehta JL; Department of Medicine, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.

Cardiovasc Drugs Ther ; 31(1): 19-27, 2017 Feb.

Article in En | MEDLINE | ID: mdl-28084571

Subject(s)

Cell Transdifferentiation/drug effects; Foam Cells/drug effects; Inflammasomes/drug effects; Muscle, Smooth, Vascular/drug effects; Myocytes, Smooth Muscle/drug effects; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism; Scavenger Receptors, Class E/metabolism; Xanthine Oxidase/pharmacology; CD36 Antigens/metabolism; Cell Line, Tumor; Foam Cells/enzymology; Humans; Inflammasomes/metabolism; Muscle, Smooth, Vascular/enzymology; Myocytes, Smooth Muscle/enzymology; NLR Family, Pyrin Domain-Containing 3 Protein/genetics; RNA Interference; Reactive Oxygen Species/metabolism; Scavenger Receptors, Class A/metabolism; Scavenger Receptors, Class E/genetics; Signal Transduction/drug effects; Transfection; Uric Acid/pharmacology

Key words

CD36; Foam cell; Lox-1; Scavenger receptors; Uric acid; Xanthine oxidase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Xanthine Oxidase / Myocytes, Smooth Muscle / Scavenger Receptors, Class E / Cell Transdifferentiation / Inflammasomes / Foam Cells / NLR Family, Pyrin Domain-Containing 3 Protein / Muscle, Smooth, Vascular Limits: Humans Language: En Journal: Cardiovasc Drugs Ther Journal subject: ANGIOLOGIA / CARDIOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States

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