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Complexation of oxethazaine with 2-hydroxypropyl-ß-cyclodextrin: increased drug solubility, decreased cytotoxicity and analgesia at inflamed tissues.
Prado, Andressa R; Yokaichiya, Fabiano; Franco, Margareth Kazuyo Kobayashi Dias; Silva, Camila Morais Gonçalves da; Oliveira-Nascimento, Laura; Franz-Montan, Michelle; Volpato, Maria C; Cabeça, Luís F; de Paula, Eneida.
Affiliation
  • Prado AR; Biochemistry and Tissue Biology Department, Biology Institute, University of Campinas (Unicamp), Campinas, SP, Brazil.
  • Yokaichiya F; Department Quantum Phenomena in Novel Materials, Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, Berlin, Germany.
  • Franco MKKD; Institute for Energetic and Nuclear Research (IPEN)/Multipurpose Brazilian Reactor, Cidade Universitária Armando Salles de Oliveira, São Paulo, SP, Brazil.
  • Silva CMGD; Biochemistry and Tissue Biology Department, Biology Institute, University of Campinas (Unicamp), Campinas, SP, Brazil.
  • Oliveira-Nascimento L; Biochemistry and Tissue Biology Department, Biology Institute, University of Campinas (Unicamp), Campinas, SP, Brazil.
  • Franz-Montan M; Faculty of Pharmaceutical Sciences, University of Campinas (Unicamp), Campinas, SP, Brazil.
  • Volpato MC; Department of Physiological Sciences, Piracicaba Dental School, University of Campinas (Unicamp), Piracicaba, SP, Brazil.
  • Cabeça LF; Department of Physiological Sciences, Piracicaba Dental School, University of Campinas (Unicamp), Piracicaba, SP, Brazil.
  • de Paula E; Technologic Federal University of Parana, Londrina, PR, Brazil.
J Pharm Pharmacol ; 69(6): 652-662, 2017 Jun.
Article in En | MEDLINE | ID: mdl-28211640
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ethanolamines / 2-Hydroxypropyl-beta-cyclodextrin / Inflammation / Anesthetics, Local Limits: Animals Language: En Journal: J Pharm Pharmacol Year: 2017 Document type: Article Affiliation country: Brazil Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ethanolamines / 2-Hydroxypropyl-beta-cyclodextrin / Inflammation / Anesthetics, Local Limits: Animals Language: En Journal: J Pharm Pharmacol Year: 2017 Document type: Article Affiliation country: Brazil Country of publication: United kingdom