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CRISPR/Cas9-Mediated CCR5 Ablation in Human Hematopoietic Stem/Progenitor Cells Confers HIV-1 Resistance In Vivo.
Xu, Lei; Yang, Huan; Gao, Yang; Chen, Zeyu; Xie, Liangfu; Liu, Yulin; Liu, Ying; Wang, Xiaobao; Li, Hanwei; Lai, Weifeng; He, Yuan; Yao, Anzhi; Ma, Liying; Shao, Yiming; Zhang, Bin; Wang, Chengyan; Chen, Hu; Deng, Hongkui.
Affiliation
  • Xu L; Department of Hematopoietic Stem Cell Transplantation, 307 Hospital of PLA, Beijing 100071, China; Cell and Gene Therapy Center, Academy of Military Medical Sciences, Beijing 100850, China.
  • Yang H; Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center; State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentia
  • Gao Y; Department of Hematopoietic Stem Cell Transplantation, 307 Hospital of PLA, Beijing 100071, China; Cell and Gene Therapy Center, Academy of Military Medical Sciences, Beijing 100850, China; Department of Hematology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
  • Chen Z; Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center; State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentia
  • Xie L; Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center; State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentia
  • Liu Y; Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center; State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentia
  • Liu Y; National Center for AIDS/STD Control and Prevention, China CDC, Beijing 102206, China.
  • Wang X; Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center; State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentia
  • Li H; Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center; State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentia
  • Lai W; Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center; State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentia
  • He Y; Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center; State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentia
  • Yao A; Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center; State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentia
  • Ma L; National Center for AIDS/STD Control and Prevention, China CDC, Beijing 102206, China.
  • Shao Y; National Center for AIDS/STD Control and Prevention, China CDC, Beijing 102206, China.
  • Zhang B; Department of Hematopoietic Stem Cell Transplantation, 307 Hospital of PLA, Beijing 100071, China; Cell and Gene Therapy Center, Academy of Military Medical Sciences, Beijing 100850, China.
  • Wang C; Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center; State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentia
  • Chen H; Department of Hematopoietic Stem Cell Transplantation, 307 Hospital of PLA, Beijing 100071, China; Cell and Gene Therapy Center, Academy of Military Medical Sciences, Beijing 100850, China. Electronic address: chenhu217@aliyun.com.
  • Deng H; Department of Cell Biology, School of Basic Medical Sciences, Peking University Stem Cell Research Center; State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Peking University, Beijing 100191, China; MOE Key Laboratory of Cell Proliferation and Differentia
Mol Ther ; 25(8): 1782-1789, 2017 08 02.
Article in En | MEDLINE | ID: mdl-28527722
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells / HIV Infections / HIV-1 / Gene Targeting / Receptors, CCR5 / CRISPR-Cas Systems Limits: Animals / Humans Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2017 Document type: Article Affiliation country: China Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells / HIV Infections / HIV-1 / Gene Targeting / Receptors, CCR5 / CRISPR-Cas Systems Limits: Animals / Humans Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2017 Document type: Article Affiliation country: China Country of publication: United States