Combination Drug Therapy of Pioglitazone and D-cycloserine Attenuates Chronic Orofacial Neuropathic Pain and Anxiety by Improving Mitochondrial Function Following Trigeminal Nerve Injury.

Lyons, Danielle N; Zhang, Liping; Pandya, Jignesh D; Danaher, Robert J; Ma, Fei; Miller, Craig S; Sullivan, Patrick G; Sirbu, Cristian; Westlund, Karin N

Lyons, Danielle N; Zhang, Liping; Pandya, Jignesh D; Danaher, Robert J; Ma, Fei; Miller, Craig S; Sullivan, Patrick G; Sirbu, Cristian; Westlund, Karin N.

Affiliation

Lyons DN; Departments of Physiology.
Zhang L; Departments of Physiology.
Pandya JD; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY.
Danaher RJ; Oral Health Practice.
Ma F; Departments of Physiology.
Miller CS; Oral Health Practice.
Sullivan PG; Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY.
Sirbu C; Charleston Area Medical Center Health Education and Research Institute, Department of Behavioral Medicine and Psychiatry West Virginia University School of Medicine Charleston Division, Morgantown, WV.
Westlund KN; Departments of Physiology.

Clin J Pain ; 34(2): 168-177, 2018 02.

Article in En | MEDLINE | ID: mdl-28542026

Subject(s)

Analgesics/pharmacology; Chronic Pain/drug therapy; Cycloserine/pharmacology; Facial Pain/drug therapy; Neuralgia/drug therapy; Pioglitazone/pharmacology; Trigeminal Nerve Injuries/drug therapy; Animals; Anti-Anxiety Agents/pharmacology; Anxiety/drug therapy; Anxiety/metabolism; Brain/drug effects; Brain/metabolism; Chronic Pain/metabolism; Chronic Pain/psychology; Cognition/drug effects; Disease Models, Animal; Drug Therapy, Combination; Facial Pain/metabolism; Facial Pain/psychology; Hyperalgesia/drug therapy; Hyperalgesia/metabolism; Hyperalgesia/psychology; Male; Mice, Inbred C57BL; Mitochondria/drug effects; Mitochondria/metabolism; Neuralgia/metabolism; Neuralgia/psychology; Random Allocation; Trigeminal Nerve Injuries/metabolism; Trigeminal Nerve Injuries/psychology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Facial Pain / Cycloserine / Trigeminal Nerve Injuries / Chronic Pain / Pioglitazone / Analgesics / Neuralgia Limits: Animals Language: En Journal: Clin J Pain Journal subject: NEUROLOGIA / PSICOFISIOLOGIA Year: 2018 Document type: Article Country of publication: United States

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