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Patchy Parasitized Skin Governs Leishmania donovani Transmission to Sand Flies.

Trends Parasitol; 33(10): 748-750, 2017 10.
Article in English | MEDLINE | ID: mdl-28867329
Doehl et al. have combined empirical data with computer simulation to demonstrate that RAG-2 mice intravenously infected with Leishmania donovani form heterogeneous skin parasite patches that govern infectiousness to sand flies. This model provides a much-needed tool to explore the relevance of asymptomatic and symptomatic visceral leishmaniasis patients as infection reservoirs.