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Antimicrobial resistance of Enterococcus in Turkey: A meta-analysis of current studies.

J Glob Antimicrob Resist; 2017 Sep 04.
Article in English | MEDLINE | ID: mdl-28882763


This study conducted a meta-analysis of Enterococcus isolates collected in 2000-2015 in Turkey and their susceptibility and resistance to antibiotics, clinical indications for the initial drug treatment, and identification of alternative treatments.


This meta-analysis examined antibiotic susceptibility and resistance in Enterococcus. The study was planned and conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The statements on antimicrobial resistance were grouped according to the Antimicrobial Stewardship Program.


The resistance rates of E. faecalis for vancomycin (VAN), linezolid (LNZ) were 1.0±2.2% and 1.9±2.6%, respectively. The average resistance of E. faecium to VAN and LNZ were 10.3±11.3% and 2.1±2.4%, respectively.


In conclusion, this study is the first meta-analysis of the resistance of clinical Enterococcus isolates in Turkey to antibiotic agents; this is a major problem stemming from the excessive usage of antibiotic agents. The development of antibiotic resistance in Turkey has changed over time. To support the practice of evidence-based medicine, more notifications about Enterococcus resistance status are needed, especially notifications following the Antimicrobial Stewardship Program rules.