Development of a Novel Multipenicillin Assay and Assessment of the Impact of Analyte Degradation: Lessons for Scavenged Sampling in Antimicrobial Pharmacokinetic Study Design.

Kipper, Karin; Barker, Charlotte I S; Standing, Joseph F; Sharland, Mike; Johnston, Atholl

Kipper, Karin; Barker, Charlotte I S; Standing, Joseph F; Sharland, Mike; Johnston, Atholl.

Affiliation

Kipper K; Paediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St. George's University of London, London, United Kingdom karin.kipper@gmail.com.
Barker CIS; University of Tartu, Institute of Chemistry, Tartu, Estonia.
Standing JF; Analytical Services International Ltd., St. George's University of London, London, United Kingdom.
Sharland M; Paediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St. George's University of London, London, United Kingdom.
Johnston A; Inflammation, Infection and Rheumatology Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.

Antimicrob Agents Chemother ; 62(1)2018 01.

Article in En | MEDLINE | ID: mdl-29084754

Subject(s)

Amoxicillin/blood; Ampicillin/blood; Anti-Bacterial Agents/blood; Floxacillin/blood; Penicillin G/blood; Piperacillin/blood; Chromatography, High Pressure Liquid; Drug Stability; Humans; Tandem Mass Spectrometry

Key words

beta-lactams; drug stability; high-pressure liquid chromatography; mass spectrometry; penicillins; pharmacokinetics; scavenged sampling

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penicillin G / Piperacillin / Floxacillin / Amoxicillin / Ampicillin / Anti-Bacterial Agents Type of study: Guideline Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2018 Document type: Article Affiliation country: United kingdom Country of publication: United States

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