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Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes.
Lyons, James S; Joca, Humberto C; Law, Robert A; Williams, Katrina M; Kerr, Jaclyn P; Shi, Guoli; Khairallah, Ramzi J; Martin, Stuart S; Konstantopoulos, Konstantinos; Ward, Christopher W; Stains, Joseph P.
Affiliation
  • Lyons JS; Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Joca HC; Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Law RA; Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Williams KM; Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Kerr JP; Department of Orthopaedics, University of Maryland School of Nursing, Baltimore, MD 21201, USA.
  • Shi G; Department of Orthopaedics, University of Maryland School of Nursing, Baltimore, MD 21201, USA.
  • Khairallah RJ; Myologica, LLC, New Market, MD 21212, USA.
  • Martin SS; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Konstantopoulos K; Department of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Ward CW; Department of Orthopaedics, University of Maryland School of Nursing, Baltimore, MD 21201, USA. jstains@som.umaryland.edu ward@umaryland.edu.
  • Stains JP; Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA. jstains@som.umaryland.edu ward@umaryland.edu.
Sci Signal ; 10(506)2017 Nov 21.
Article in En | MEDLINE | ID: mdl-29162742
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteocytes / Glycoproteins / Mechanotransduction, Cellular / TRPV Cation Channels / NADPH Oxidase 2 / Microtubules Type of study: Prognostic_studies Limits: Animals Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteocytes / Glycoproteins / Mechanotransduction, Cellular / TRPV Cation Channels / NADPH Oxidase 2 / Microtubules Type of study: Prognostic_studies Limits: Animals Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States