Inhalation of Fine Particulate Matter Impairs Endothelial Progenitor Cell Function Via Pulmonary Oxidative Stress.

Haberzettl, Petra; Conklin, Daniel J; Abplanalp, Wesley T; Bhatnagar, Aruni; O'Toole, Timothy E

Haberzettl, Petra; Conklin, Daniel J; Abplanalp, Wesley T; Bhatnagar, Aruni; O'Toole, Timothy E.

Affiliation

Haberzettl P; From the Department of Medicine, Diabetes and Obesity Center, Institute of Molecular Cardiology, University of Louisville, KY.
Conklin DJ; From the Department of Medicine, Diabetes and Obesity Center, Institute of Molecular Cardiology, University of Louisville, KY.
Abplanalp WT; From the Department of Medicine, Diabetes and Obesity Center, Institute of Molecular Cardiology, University of Louisville, KY.
Bhatnagar A; From the Department of Medicine, Diabetes and Obesity Center, Institute of Molecular Cardiology, University of Louisville, KY.
O'Toole TE; From the Department of Medicine, Diabetes and Obesity Center, Institute of Molecular Cardiology, University of Louisville, KY. tim.otoole@louisville.edu.

Arterioscler Thromb Vasc Biol ; 38(1): 131-142, 2018 01.

Article in En | MEDLINE | ID: mdl-29191925

Subject(s)

Endothelial Progenitor Cells/drug effects; Endothelial Progenitor Cells/transplantation; Inhalation Exposure/adverse effects; Ischemia/surgery; Lung/drug effects; Muscle, Skeletal/blood supply; Neovascularization, Physiologic/drug effects; Oxidative Stress/drug effects; Particulate Matter/toxicity; Animals; Cell Movement/drug effects; Cell Proliferation/drug effects; Cells, Cultured; Disease Models, Animal; Endothelial Progenitor Cells/metabolism; Endothelial Progenitor Cells/pathology; Hindlimb; Ischemia/metabolism; Ischemia/pathology; Ischemia/physiopathology; Lung/metabolism; Lung/pathology; Male; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide/metabolism; Nitric Oxide Synthase Type III/metabolism; Particle Size; Superoxide Dismutase/genetics; Superoxide Dismutase/metabolism; Vascular Endothelial Growth Factor A/pharmacology

Key words

air pollution; endothelial progenitor cells; hind limb ischemia; mice; particulate matter

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidative Stress / Muscle, Skeletal / Neovascularization, Physiologic / Inhalation Exposure / Particulate Matter / Endothelial Progenitor Cells / Ischemia / Lung Type of study: Prognostic_studies Limits: Animals Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2018 Document type: Article Country of publication: United States

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