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Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming.
Geter, Phillip A; Ernlund, Amanda W; Bakogianni, Sofia; Alard, Amandine; Arju, Rezina; Giashuddin, Shah; Gadi, Abhilash; Bromberg, Jacqueline; Schneider, Robert J.
Affiliation
  • Geter PA; Department of Microbiology, Alexandria Center for Life Science, New York University School of Medicine, New York, New York 10016, USA.
  • Ernlund AW; Department of Microbiology, Alexandria Center for Life Science, New York University School of Medicine, New York, New York 10016, USA.
  • Bakogianni S; Department of Microbiology, Alexandria Center for Life Science, New York University School of Medicine, New York, New York 10016, USA.
  • Alard A; Department of Microbiology, Alexandria Center for Life Science, New York University School of Medicine, New York, New York 10016, USA.
  • Arju R; Department of Microbiology, Alexandria Center for Life Science, New York University School of Medicine, New York, New York 10016, USA.
  • Giashuddin S; New York Presbyterian-Brooklyn Methodist Hospital, Brooklyn, New York 11215, USA.
  • Gadi A; Department of Microbiology, Alexandria Center for Life Science, New York University School of Medicine, New York, New York 10016, USA.
  • Bromberg J; Memorial Sloan Kettering Cancer Institute, New York, New York 10016 USA.
  • Schneider RJ; Perlmutter Cancer Center, New York University School of Medicine, New York, New York 10016 USA.
Genes Dev ; 31(22): 2235-2249, 2017 11 15.
Article in En | MEDLINE | ID: mdl-29269484
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tamoxifen / Protein Biosynthesis / Breast Neoplasms / Protein Serine-Threonine Kinases / Antineoplastic Agents, Hormonal / Eukaryotic Initiation Factor-4E / Intracellular Signaling Peptides and Proteins / Estrogen Antagonists / Mechanistic Target of Rapamycin Complex 1 Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Genes Dev Journal subject: BIOLOGIA MOLECULAR Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tamoxifen / Protein Biosynthesis / Breast Neoplasms / Protein Serine-Threonine Kinases / Antineoplastic Agents, Hormonal / Eukaryotic Initiation Factor-4E / Intracellular Signaling Peptides and Proteins / Estrogen Antagonists / Mechanistic Target of Rapamycin Complex 1 Type of study: Prognostic_studies Limits: Female / Humans Language: En Journal: Genes Dev Journal subject: BIOLOGIA MOLECULAR Year: 2017 Document type: Article Affiliation country: United States Country of publication: United States