MicroRNA-146a-5p attenuates visceral hypersensitivity through targeting chemokine CCL8 in the spinal cord in a mouse model of colitis.

Lu, Ying; Cao, De-Li; Zhao, Lin-Xia; Han, Yu; Zhang, You-Li

Lu, Ying; Cao, De-Li; Zhao, Lin-Xia; Han, Yu; Zhang, You-Li.

Affiliation

Lu Y; Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China; Department of Nutrition and Food Hygiene, School of Public Health, Nantong University, Nantong, Jiangsu 226019, China.
Cao DL; Pain Research Laboratory, Institute of Nautical Medicine, Nantong University, Nantong, Jiangsu 226019, China.
Zhao LX; Pain Research Laboratory, Institute of Nautical Medicine, Nantong University, Nantong, Jiangsu 226019, China.
Han Y; Department of Occupational Medicine and Environmental Hygiene, School of Public Health, Nantong University, Nantong, Jiangsu 226019, China.
Zhang YL; Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China. Electronic address: zhangyouli1957@163.com.

Brain Res Bull ; 139: 235-242, 2018 05.

Article in En | MEDLINE | ID: mdl-29550454

Subject(s)

Chemokine CCL8/metabolism; Colitis/complications; Gene Expression Regulation/genetics; MicroRNAs/therapeutic use; Spinal Cord/metabolism; Visceral Pain; Animals; Antagomirs/therapeutic use; Antibodies/therapeutic use; Cells, Cultured; Chemokine CCL8/chemistry; Chemokine CCL8/genetics; Chemokine CCL8/immunology; Colitis/chemically induced; Colitis/pathology; Disease Models, Animal; Gene Expression Regulation/drug effects; Humans; Hyperalgesia/metabolism; Male; Mice; Mice, Inbred C57BL; MicroRNAs/chemistry; MicroRNAs/metabolism; Peroxidase/metabolism; RNA, Small Interfering/therapeutic use; Spinal Cord/drug effects; Trinitrobenzenesulfonic Acid/toxicity; Tumor Necrosis Factor-alpha/pharmacology; Up-Regulation/drug effects; Visceral Pain/etiology; Visceral Pain/pathology; Visceral Pain/therapy

Key words

CCL8; Colitis; MiR-146a-5p; TNBS; Visceral pain

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord / Gene Expression Regulation / Colitis / MicroRNAs / Chemokine CCL8 / Visceral Pain Type of study: Etiology_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Brain Res Bull Year: 2018 Document type: Article Affiliation country: China Country of publication: United States

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