Protein Nanoparticles Promote Microparticle Formation in Intravenous Immunoglobulin Solutions During Freeze-Thawing and Agitation Stresses.

Pardeshi, Neha N; Zhou, Chen; Randolph, Theodore W; Carpenter, John F

Pardeshi, Neha N; Zhou, Chen; Randolph, Theodore W; Carpenter, John F.

Affiliation

Pardeshi NN; Department of Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045.
Zhou C; Department of Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045.
Randolph TW; Department of Chemical and Biological Engineering, University of Colorado, Boulder, Colorado 80309.
Carpenter JF; Department of Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045. Electronic address: john.carpenter@ucdenver.edu.

J Pharm Sci ; 107(7): 1852-1857, 2018 07.

Article in En | MEDLINE | ID: mdl-29601840

Subject(s)

Immunoglobulins, Intravenous/chemistry; Nanoparticles/chemistry; Protein Aggregates; Centrifugation; Drug Stability; Freezing; Hot Temperature; Particle Size; Protein Stability; Stress, Mechanical

Key words

adsorption; degradation product(s); desorption; formulation; mAb(s); microparticle(s); nanoparticle(s); physical stability; protein aggregation; surfactant(s)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulins, Intravenous / Nanoparticles / Protein Aggregates Language: En Journal: J Pharm Sci Year: 2018 Document type: Article Country of publication: United States

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