Atorvastatin induces MicroRNA-145 expression in HEPG2 cells via regulation of the PI3K/AKT signalling pathway.

Docrat, Taskeen Fathima; Nagiah, Savania; Krishnan, Anand; Naidoo, Dhaneshree B; Chuturgoon, Anil A

Docrat, Taskeen Fathima; Nagiah, Savania; Krishnan, Anand; Naidoo, Dhaneshree B; Chuturgoon, Anil A.

Affiliation

Docrat TF; Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Sciences, College of Health Science, University of KwaZulu-Natal, South Africa.
Nagiah S; Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Sciences, College of Health Science, University of KwaZulu-Natal, South Africa.
Krishnan A; Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Sciences, College of Health Science, University of KwaZulu-Natal, South Africa.
Naidoo DB; Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Sciences, College of Health Science, University of KwaZulu-Natal, South Africa.
Chuturgoon AA; Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Sciences, College of Health Science, University of KwaZulu-Natal, South Africa. Electronic address: chutur@ukzn.ac.za.

Chem Biol Interact ; 287: 32-40, 2018 May 01.

Article in En | MEDLINE | ID: mdl-29630879

Subject(s)

Antineoplastic Agents/toxicity; Apoptosis/drug effects; Atorvastatin/toxicity; MicroRNAs/metabolism; Signal Transduction/drug effects; Up-Regulation/drug effects; Caspases/metabolism; Down-Regulation/drug effects; Enzyme-Linked Immunosorbent Assay; Glycogen Synthase Kinase 3 beta/metabolism; Hep G2 Cells; Humans; Malondialdehyde/analysis; Oxidative Stress/drug effects; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Proto-Oncogene Proteins c-mdm2/metabolism; Tumor Necrosis Factor-alpha/analysis; Tumor Suppressor Protein p53/metabolism

Key words

Atorvastatin; HepG2; PI3K/Akt; miRNA-145

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Up-Regulation / Apoptosis / MicroRNAs / Atorvastatin / Antineoplastic Agents Limits: Humans Language: En Journal: Chem Biol Interact Year: 2018 Document type: Article Affiliation country: South Africa Country of publication: Ireland

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