The doses of plasmid backbone plays a major role in determining the HBV clearance in hydrodynamic injection mouse model.

Wang, Xian; Zhu, Jianmin; Zhang, Yong; Li, Yue; Ma, Tai; Li, Qun; Xu, Jiegou; Xu, Long

Wang, Xian; Zhu, Jianmin; Zhang, Yong; Li, Yue; Ma, Tai; Li, Qun; Xu, Jiegou; Xu, Long.

Affiliation

Wang X; School of Basic Medical Sciences, Anhui Medical University, 81#Mei Shan Road, Hefei, 230032, Anhui, China.
Zhu J; Department of Pathology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Zhang Y; Pediatric Translational Medicine Institute, Shanghai Children' s Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Li Y; Department of Spine Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Ma T; School of Basic Medical Sciences, Anhui Medical University, 81#Mei Shan Road, Hefei, 230032, Anhui, China.
Li Q; School of Basic Medical Sciences, Anhui Medical University, 81#Mei Shan Road, Hefei, 230032, Anhui, China.
Xu J; School of Basic Medical Sciences, Anhui Medical University, 81#Mei Shan Road, Hefei, 230032, Anhui, China.
Xu L; School of Basic Medical Sciences, Anhui Medical University, 81#Mei Shan Road, Hefei, 230032, Anhui, China.

Virol J ; 15(1): 89, 2018 05 21.

Article in En | MEDLINE | ID: mdl-29783985

Subject(s)

Genetic Vectors/immunology; Hepatitis B virus/immunology; Hepatitis B/immunology; Host-Pathogen Interactions/immunology; Liver/immunology; Plasmids/immunology; Animals; Biolistics/methods; Dependovirus/genetics; Dependovirus/immunology; Disease Models, Animal; Gene Dosage; Gene Expression Regulation; Genetic Vectors/metabolism; Hepatitis B/genetics; Hepatitis B/virology; Hepatitis B Core Antigens/genetics; Hepatitis B Core Antigens/immunology; Hepatitis B Surface Antigens/genetics; Hepatitis B Surface Antigens/immunology; Hepatitis B virus/genetics; Host-Pathogen Interactions/genetics; Hydrodynamics; Interferon Type I/genetics; Interferon Type I/immunology; Liver/virology; Male; Mice; Mice, Inbred C57BL; Plasmids/metabolism; Receptors, CXCR3/genetics; Receptors, CXCR3/immunology; Signal Transduction; T-Box Domain Proteins/genetics; T-Box Domain Proteins/immunology; Th1 Cells/immunology; Th1 Cells/virology; Toll-Like Receptors/genetics; Toll-Like Receptors/immunology; Transfection/methods

Key words

HBcAg; Hepatitis B virus; Hydrodynamic injection; Mouse model; Plasmid backbone

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmids / Hepatitis B virus / Host-Pathogen Interactions / Genetic Vectors / Hepatitis B / Liver Type of study: Prognostic_studies Language: En Journal: Virol J Journal subject: VIROLOGIA Year: 2018 Document type: Article Affiliation country: China Country of publication: United kingdom

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