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A first-in-human study investigating biodistribution, safety and recommended dose of a new radiolabeled MAb targeting FZD10 in metastatic synovial sarcoma patients.
Giraudet, Anne-Laure; Cassier, Philippe Alexandre; Iwao-Fukukawa, Chicaco; Garin, Gwenaelle; Badel, Jean-Noël; Kryza, David; Chabaud, Sylvie; Gilles-Afchain, Laurence; Clapisson, Gilles; Desuzinges, Claude; Sarrut, David; Halty, Adrien; Italiano, Antoine; Mori, Masaharu; Tsunoda, Takuya; Katagiri, Toyomasa; Nakamura, Yusuke; Alberti, Laurent; Cropet, Claire; Baconnier, Simon; Berge-Montamat, Sandrine; Pérol, David; Blay, Jean-Yves.
Affiliation
  • Giraudet AL; Department of Nuclear Medicine, LUMEN, Centre Léon Bérard, 28 Rue Laennec, 69008, Lyon, France. anne-laure.giraudet@lyon.unicancer.fr.
  • Cassier PA; Medical Oncology Department, Centre Léon Bérard, Lyon, France.
  • Iwao-Fukukawa C; OncoTherapy Science, Kawasaki City, Kanagawa Prefecture, Japan.
  • Garin G; Clinical Research Platform, DRCI, Centre Léon Bérard, Lyon, France.
  • Badel JN; Department of Nuclear Medicine, LUMEN, Centre Léon Bérard, 28 Rue Laennec, 69008, Lyon, France.
  • Kryza D; Université Lyon 1, CNRS, LAGEP UMR 5007, HCL, Lyon, France.
  • Chabaud S; Clinical Research Platform, DRCI, Centre Léon Bérard, Lyon, France.
  • Gilles-Afchain L; Pharmacy, Centre Léon Bérard, Lyon, France.
  • Clapisson G; Biological sample Management Platform (PGEB), Centre Léon Bérard, Lyon, France.
  • Desuzinges C; Department of Nuclear Medicine, LUMEN, Centre Léon Bérard, 28 Rue Laennec, 69008, Lyon, France.
  • Sarrut D; INSA-Lyon, Université Lyon 1, CNRS, Inserm, CREATIS UMR 5220, U1206, Lyon, France.
  • Halty A; INSA-Lyon, Université Lyon 1, CNRS, Inserm, CREATIS UMR 5220, U1206, Lyon, France.
  • Italiano A; Institut Bergonié, Bordeaux, France.
  • Mori M; Division of Genome Medicine, Institute for Genome Research, The University of Tokushima, Tokushima, Japan.
  • Tsunoda T; Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Katagiri T; Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Nakamura Y; Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
  • Alberti L; Present Address: Department of Medicine and Surgery, The University of Chicago, Tokyo, Japan.
  • Cropet C; Fédération de Recherche Santé Lyon-Est, CNRS UMS3453/INSERM US7, Lyon, France.
  • Baconnier S; Clinical Research Platform, DRCI, Centre Léon Bérard, Lyon, France.
  • Berge-Montamat S; Medical Oncology Department, Centre Léon Bérard, Lyon, France.
  • Pérol D; Medical Oncology Department, Centre Léon Bérard, Lyon, France.
  • Blay JY; Clinical Research Platform, DRCI, Centre Léon Bérard, Lyon, France.
BMC Cancer ; 18(1): 646, 2018 Jun 08.
Article in En | MEDLINE | ID: mdl-29884132
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Yttrium Radioisotopes / Radioimmunotherapy / Sarcoma, Synovial / Frizzled Receptors / Antineoplastic Agents, Immunological Type of study: Clinical_trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: BMC Cancer Journal subject: NEOPLASIAS Year: 2018 Document type: Article Affiliation country: France Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Yttrium Radioisotopes / Radioimmunotherapy / Sarcoma, Synovial / Frizzled Receptors / Antineoplastic Agents, Immunological Type of study: Clinical_trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: BMC Cancer Journal subject: NEOPLASIAS Year: 2018 Document type: Article Affiliation country: France Country of publication: United kingdom