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mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3ß/C/EBPα signaling pathway.
Yang, Han-Wei; Hong, Hui-Ling; Luo, Wen-Wei; Dai, Chun-Mei; Chen, Xin-Yi; Wang, Lu-Ping; Li, Qian; Li, Zi-Qing; Liu, Pei-Qing; Li, Zhuo-Ming.
Affiliation
  • Yang HW; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Hong HL; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.
  • Luo WW; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Dai CM; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.
  • Chen XY; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Wang LP; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.
  • Li Q; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Li ZQ; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.
  • Liu PQ; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
  • Li ZM; National and Local United Engineering Lab of Druggability and New Drugs Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.
Acta Pharmacol Sin ; 39(12): 1837-1846, 2018 Dec.
Article in En | MEDLINE | ID: mdl-29991711
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cellular Senescence / Endothelial Cells / Mechanistic Target of Rapamycin Complex 2 Type of study: Prognostic_studies Limits: Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2018 Document type: Article Affiliation country: China Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cellular Senescence / Endothelial Cells / Mechanistic Target of Rapamycin Complex 2 Type of study: Prognostic_studies Limits: Humans Language: En Journal: Acta Pharmacol Sin Journal subject: FARMACOLOGIA Year: 2018 Document type: Article Affiliation country: China Country of publication: United States