Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study
Lancet
; 390(10107): 2050-2062, 2017.
Article
in English
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1064598
Responsible library:
BR79.1
Localization: BR79.1
ABSTRACT
BACKGROUND:
The relationship between macronutrients and cardiovascular disease and mortality is controversial. Most available data are from European and North American populations where nutrition excess is more likely, so their applicability to other populations is unclear.METHODS:
The Prospective Urban Rural Epidemiology (PURE) study is a large, epidemiological cohort study of individuals aged 35-70 years (enrolled between Jan 1, 2003, and March 31, 2013) in 18 countries with a median follow-up of 7·4 years (IQR 5·3-9·3). Dietary intake of 135 335 individuals was recorded using validated food frequency questionnaires. The primary outcomes were total mortality and major cardiovascular events (fatal cardiovascular disease, non-fatal myocardial infarction, stroke, and heart failure). Secondary outcomes were all myocardial infarctions, stroke, cardiovascular disease mortality, and non-cardiovascular disease mortality. Participants were categorised into quintiles of nutrient intake (carbohydrate, fats, and protein) based on percentage of energy provided by nutrients. We assessed the associations between consumption of carbohydrate, total fat, and each type of fat with cardiovascular disease and total mortality. We calculated hazard ratios (HRs) using a multivariable Cox frailty model with random intercepts to account for centre clustering...
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Collection:
National databases
/
Brazil
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Cardiovascular Disease
Database:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Main subject:
Carbohydrates
/
Mortality
/
Eating
/
Fats
/
Heart Diseases
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Language:
English
Journal:
Lancet
Year:
2017
Document type:
Article
Institution/Affiliation country:
Centre of Excellence for Nutrition, Faculty of Health Sciences, North-West University/ZA
/
Department of Medicine, McMaster University/CA
/
Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg/SE
/
Departments of Community Health Sciences and Medicine, Aga Khan University/PK
/
Division of Angiology, Wroclaw Medical University/PL
/
Dubai Medical University, Hatta Hospital/AE
/
Estudios Clínicos Latinoamérica, ECLA/AR
/
Eternal Heart Care Centre and Research Institute/IN
/
Faculty of Health Sciences, Department of Biomedical Physiology & Kinesiology, Simon Fraser University/CA
/
Faculty of Medicine, Universiti Teknologi MARA/MY