The role of the CNR1 gene in schizophrenia: a systematic review including unpublished data
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 39(2): 160-171, Apr.-June 2017. tab, graf
Artículo
en Inglés
| LILACS
| ID: biblio-844185
Biblioteca responsable:
BR1.1
ABSTRACT
Objective:
Schizophrenia is a multifactorial disorder. It is known that a combination of extensive multiple common alleles may be involved in its etiology, each contributing with a small to moderate effect, and, possibly, some rare alleles with a much larger effect size. We aimed to perform a systematic review of association studies between schizophrenia (and its subphenotypes) and polymorphisms in the CNR1 gene, which encodes cannabinoid receptors classically implicated in schizophrenia pathophysiology, as well as to present unpublished results of an association study in a Brazilian population.Methods:
Two reviewers independently searched for eligible studies and extracted outcome data using a structured form. Papers were retrieved from PubMed and ISI Web of Knowledge using the search term schizophrenia in combination with CNR1 or CB1 or cannabinoid receptor. Twenty-four articles met our inclusion criteria. We additionally present data from a study of our own comparing 182 patients with schizophrenia and 244 healthy controls.Results:
No consistent evidence is demonstrated.Conclusion:
Some seemingly positive association studies stress the need for further investigations of the possible role of endocannabinoid genetics in schizophrenia.
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
LILACS
Asunto principal:
Esquizofrenia
/
Polimorfismo de Nucleótido Simple
/
Receptor Cannabinoide CB1
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
/
Revisión sistemática
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Asunto de la revista:
Psiquiatria
Año:
2017
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal de São Paulo/BR