Medicinal mushrooms in adjuvant cancer therapies: an approach to anticancer effects and presumed mechanisms of action
Nutrire Rev. Soc. Bras. Aliment. Nutr
; 42: 1-10, Dec. 2017. tab
Artículo
en Inglés
| LILACS
| ID: biblio-880616
Biblioteca responsable:
BR1600.9
ABSTRACT
Mushrooms have been used for centuries as a source of nourishment and sensory properties. Mushrooms are considered functional foods due to their bioactive compounds and a source of drug and nutraceutical development. More than 50 species present immunological potential that exhibit anticancer activity in vitro or in animal models, and some of them have been investigated in human cancers. Cancer is a major cause of death all over the world, promoting long lasting effects throughout the lifetime of the patient. Mushrooms are a source of ergothioneine, selenium, fiber, and several other vitamins and minerals. They have bioactive compounds used in cancer treatment due to their antitumor and anticarcinogenic effects. They containß-glucans,ß-proteoglycans, lectins, triterpenes, ergosterol, glutamine, and arginine. In the present study, we perform a literature review of studies that analyze positive impacts of mushroom compounds on cancer treatment due to their antitumor and anticarcinogenic effects and possible compatibility with chemotherapy management. The review indicates that a healthy diet with frequent consumption of mushrooms apparently reduces the risk of developing cancer. However, a clearer understanding of how mushrooms' bioactive principles may affect adjuvant treatments requires further research with long-term double-blind and placebo-controlled studies that evaluate a larger population in clinical trials by each type of cancer. There fore, more robust statistical results are necessary to verify their efficacy and safety on cancer treatments
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
LILACS
Asunto principal:
Agaricales
/
Antineoplásicos
Tipo de estudio:
Ensayo clínico controlado
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Nutrire Rev. Soc. Bras. Aliment. Nutr
Asunto de la revista:
Ciencias Nutricionales
Año:
2017
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Catholic University of Minas Gerais/BR