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Efficacy of targeted therapy for advanced renal cell carcinoma: A systematic review and meta-analysis of randomized controlled trials
Wei, Chao; Wang, Shen; Ye, Zhangqun; Chen, Zhiqiang.
Afiliación
  • Wei, Chao; Huazhong University of Science and Technology. Tongji Hospital, Tongji Medical College. Department of Urology. Wuhan. CN
  • Wang, Shen; Huazhong University of Science and Technology. Tongji Hospital, Tongji Medical College. Department of Urology. Wuhan. CN
  • Ye, Zhangqun; Huazhong University of Science and Technology. Tongji Hospital, Tongji Medical College. Department of Urology. Wuhan. CN
  • Chen, Zhiqiang; Huazhong University of Science and Technology. Tongji Hospital, Tongji Medical College. Department of Urology. Wuhan. CN
Int. braz. j. urol ; 44(2): 219-237, Mar.-Apr. 2018. tab, graf
Artículo en Inglés | LILACS | ID: biblio-892967
Biblioteca responsable: BR1.1
ABSTRACT
ABSTRACT We conducted a systematic review and meta-analysis of the literature on the efficacy of the targeted therapies in the treatment of advanced RCC and, via an indirect comparison, to provide an optimal treatment among these agents. A systematic search of Medline, Scopus, Cochrane Library and Clinical Trials unpublished was performed up to Jan 1, 2015 to identify eligible randomized trials. Outcomes of interest assessing a targeted agent included progression free survival (PFS), overall survival (OS) and objective response rate (ORR). Thirty eligible randomized controlled studies, total twentyfourth trails (5110 cases and 4626 controls) were identified. Compared with placebo and IFN-α, single vascular epithelial growth factor (receptor) tyrosine kinase inhibitor and mammalian target of rapamycin agent (VEGF(r)-TKI & mTOR inhibitor) were associated with improved PFS, improved OS and higher ORR, respectively. Comparing sorafenib combination vs sorafenib, there was no significant difference with regard to PFS and OS, but with a higher ORR. Comparing single or combination VEGF(r)-TKI & mTOR inhibitor vs BEV + IFN-α, there was no significant difference with regard to PFS, OS, or ORR. Our network ITC meta-analysis also indicated a superior PFS of axitinib and everolimus compared to sorafenib. Our data suggest that targeted therapy with VEGF(r)-TKI & mTOR inhibitor is associated with superior efficacy for treating advanced RCC with improved PFS, OS and higher ORR compared to placebo and IFN-α. In summary, here we give a comprehensive overview of current targeted therapies of advanced RCC that may provide evidence for the adequate targeted therapy selecting.
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Texto completo: Disponible Colección: Bases de datos internacionales Contexto en salud: Agenda de Salud Sostenible para las Américas / ODS3 - Salud y Bienestar Problema de salud: Objetivo 9: Enfermedades no transmisibles y salud mental / Meta 3.4: Reducir las muertes prematuras por enfermedades no transmisibles Base de datos: LILACS Asunto principal: Carcinoma de Células Renales / Terapia Molecular Dirigida / Neoplasias Renales Tipo de estudio: Ensayo clínico controlado / Estudio pronóstico / Revisión sistemática Límite: Humanos Idioma: Inglés Revista: Int. braz. j. urol Asunto de la revista: Urología Año: 2018 Tipo del documento: Artículo País de afiliación: China Institución/País de afiliación: Huazhong University of Science and Technology/CN

Texto completo: Disponible Colección: Bases de datos internacionales Contexto en salud: Agenda de Salud Sostenible para las Américas / ODS3 - Salud y Bienestar Problema de salud: Objetivo 9: Enfermedades no transmisibles y salud mental / Meta 3.4: Reducir las muertes prematuras por enfermedades no transmisibles Base de datos: LILACS Asunto principal: Carcinoma de Células Renales / Terapia Molecular Dirigida / Neoplasias Renales Tipo de estudio: Ensayo clínico controlado / Estudio pronóstico / Revisión sistemática Límite: Humanos Idioma: Inglés Revista: Int. braz. j. urol Asunto de la revista: Urología Año: 2018 Tipo del documento: Artículo País de afiliación: China Institución/País de afiliación: Huazhong University of Science and Technology/CN
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