Effect of melatonin on myocardial oxidative stress induced by experimental obstructive jaundice
Rev. esp. enferm. dig
; 101(7): 460-463, jul. 2009. tab, ilus
Artículo
en Inglés
| IBECS
| ID: ibc-74429
Biblioteca responsable:
ES1.1
Ubicación: BNCS
ABSTRACT
Objective:
melatonin has been demonstrated to have activeantioxidant properties in different tissues during experimentalcholestasis. The aim of this research was to study myocardial oxidativestress on obstructive jaundice, and to analyze the effect ofmelatonin on myocardial oxidative lesions.Material andmethods:
we achieved cholestasis by ligatureand sectioning of the main bile duct. Melatonin was administeredintraperitoneally (500 ìg/kg/day). We measured malondialdehyde(MDA), reduced glutathione (GSH), catalase (CAT), superoxidedismutase (SOD) and glutathione peroxydase (GPx) antioxidantenzyme levels in the heart tissue.Results:
obstructive cholestasis increased MDA and decreasedGSH as well as all antioxidant enzymes. Melatonin administrationsignificantly decreased MDA values, and increased GSH and antioxidantenzymes on the icteric animal myocardium.Conclusions:
melatonin treatment prevents oxidative stressin the cardiac tissue as induced by experimental cholestasis(AU)
Texto completo:
Disponible
Colección:
Bases de datos nacionales
/
España
Base de datos:
IBECS
Asunto principal:
Estrés Oxidativo
/
Ictericia Obstructiva
/
Melatonina
/
Miocardio
/
Antioxidantes
Tipo de estudio:
Estudio diagnóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Rev. esp. enferm. dig
Año:
2009
Tipo del documento:
Artículo
Institución/País de afiliación:
Reina Sofía University Hospital/Spain
/
University of Córdoba/Spain