FASN expression, angiogenesis and lymphangiogenesis in central and peripheral giant cell lesions
J. appl. oral sci
; 22(2): 131-137, Mar-Apr/2014. tab, graf
Artículo
en Inglés
| LILACS, BBO - Odontología
| ID: lil-704194
Biblioteca responsable:
BR1.1
ABSTRACT
Central giant cell lesion (CGCL) and peripheral giant cell lesion (PGCL) are non-neoplastic proliferative processes of the jaws. PGCL is a reactive process induced by irritant local factors and CGCL is an intra-osseous lesion of unknown etiology. Both lesions exhibit similar histologic features showing abundant mononuclear cells, admixed with a large number of multinucleated giant cells and a rich vascularized stroma with extravasated erythrocytes, hemosiderin deposition, and blood-filled pools. Recent studies have linked fatty acid synthase (FASN) with angiogenesis. Objective:
To evaluate angiogenesis and lymphangiogenesis and their relationship with FASN expression in CGCL and PGCL. Material andMethods:
Thirteen CGCL and 14 PGCL of the jaws were selected for immunoexpression of FASN; CD34 and CD105 (to assess blood microvessel density [MVD] and microvessel area [MVA]); and D2-40 (to assess lymphatic MVD and MVA).Results:
Within PGCL and CGCL, MVD-CD34 was signifcantly higher than MVD-CD10S, followed by MVD-D2-40. Moreover, a signifcantly higher number of FASN-positive multinucleated giant cells than mononuclear cells were observed. Between PGCL and CGCL, only MVD-CD34 and all MVA were signifcantly higher in PGCL. Positive correlation between MVA-CD10S with FASNpositive mononuclear cells in both lesions was observed.Conclusions:
Our results show both lesions exhibiting similar levels of FASN expression and neoangiogenesis, suggesting constitutive processes that regulate tissue maintenance. .
Texto completo:
Disponible
Colección:
Bases de datos internacionales
Base de datos:
BBO - Odontología
/
LILACS
Asunto principal:
Enfermedades Maxilomandibulares
/
Células Gigantes
/
Linfangiogénesis
/
Acido Graso Sintasa Tipo I
/
Neovascularización Patológica
Tipo de estudio:
Estudio de evaluación
/
Estudio observacional
Límite:
Adolescente
/
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
J. appl. oral sci
Asunto de la revista:
Odontología
Año:
2014
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Federal University of Vales do Jequitinhonha e Mucuri/BR