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Monoamine metabolism study in severe, early-onset epilepsy in childhood.

Epileptic Disord; 10(2): 130-5, 2008 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-18539563

PURPOSE:

To investigate the possible dysfunction of monoamine metabolism in patients with early-onset, epileptic encephalopathies.

METHODS:

The CSF dopamine, serotonin and biopterin metabolites were studied in 37 patients with severe, mostly drug-resistant epilepsy.

RESULTS:

No significant abnormality was found, whatever the type of epilepsy, cryptogenic or symptomatic.

CONCLUSIONS:

The present study failed to demonstrate that dysfunction of the main neurotransmitters pathways is a common phenomenon in children with early-onset, severe epileptic encephalopathy.