Exome sequencing reveals the genetic landscape and frequent inactivation of PCDHB3 in Chinese rectal cancers.

Ye, Wen; Ling, Shaoping; Liu, Ran-Yi; Pan, Zhi-Zhong; Wang, Gaoyuan; Gao, Shijuan; Wu, Jiangxue; Cao, Lihua; Dong, Lili; Li, Yingchang; Zhou, Yi; Du, Wuying; Meng, Xiangqi; Chen, Jinna; Guan, Xinyuan; He, Yulong; Pan, Changchuan; Zheng, Xf Steven; Lu, Xuemei; Chen, Shuai; Huang, Wenlin

Ye, Wen; Ling, Shaoping; Liu, Ran-Yi; Pan, Zhi-Zhong; Wang, Gaoyuan; Gao, Shijuan; Wu, Jiangxue; Cao, Lihua; Dong, Lili; Li, Yingchang; Zhou, Yi; Du, Wuying; Meng, Xiangqi; Chen, Jinna; Guan, Xinyuan; He, Yulong; Pan, Changchuan; Zheng, Xf Steven; Lu, Xuemei; Chen, Shuai; Huang, Wenlin.

Afiliación

Ye W; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, PR China.
Ling S; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, PR China.
Liu RY; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, PR China.
Pan ZZ; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, PR China.
Wang G; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, PR China.
Gao S; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China.
Wu J; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, PR China.
Cao L; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, PR China.
Dong L; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, PR China.
Li Y; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, PR China.
Zhou Y; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, PR China.
Du W; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, PR China.
Meng X; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, PR China.
Chen J; Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, PR China.
Guan X; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, PR China.
He Y; Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, PR China.
Pan C; Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, PR China.
Zheng XS; Medical Oncology, Sichuan Cancer Hospital and Institute, Second People's Hospital of Sichuan Province, Chengdu, PR China.
Lu X; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, PR China.
Chen S; Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
Huang W; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, PR China.

J Pathol ; 245(2): 222-234, 2018 06.

Article en En | MEDLINE | ID: mdl-29537081

Asunto(s)

Biomarcadores de Tumor/genética; Cadherinas/genética; Neoplasias Colorrectales/genética; Secuenciación del Exoma; Silenciador del Gen; Genes Supresores de Tumor; Mutación; Adulto; Anciano; Animales; Pueblo Asiatico/genética; Biomarcadores de Tumor/metabolismo; Cadherinas/metabolismo; Línea Celular Tumoral; Movimiento Celular; Proliferación Celular; China; Neoplasias Colorrectales/etnología; Neoplasias Colorrectales/metabolismo; Neoplasias Colorrectales/patología; Islas de CpG; Metilación de ADN; Regulación hacia Abajo; Femenino; Dosificación de Gen; Regulación Neoplásica de la Expresión Génica; Predisposición Genética a la Enfermedad; Humanos; Masculino; Ratones Endogámicos BALB C; Ratones Desnudos; Persona de Mediana Edad; FN-kappa B/genética; FN-kappa B/metabolismo; Fenotipo; Protocadherinas

Palabras clave

PCDHB3; colorectal cancer; gene mutation; prognostic marker; tumor suppressor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Biomarcadores de Tumor / Cadherinas / Genes Supresores de Tumor / Silenciador del Gen / Secuenciación del Exoma / Mutación Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Pathol Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido

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