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Hydrocortisone release from tablets based on bioresorbable poly(ether-ester-urethane)s
Orozco-Castellanos, Luis Manuel; Marcos-Fernández, Angel; Alonso-Castro, Angel Josabad; González-García, Gerardo; Báez-García, José Eduardo; Rivera-Leyva, Julio Cesar; Zapata-Morales, Juan Ramón; Ruiz-Padilla, Alan Joel.
Afiliação
  • Orozco-Castellanos, Luis Manuel; University of Guanajuato. Division of Natural and Exact Sciences. Guanajuato. MX
  • Marcos-Fernández, Angel; Superior Council of Scientific Investigations. Institute of science and technology of polymers. Madri. ES
  • Alonso-Castro, Angel Josabad; University of Guanajuato. Division of Natural and Exact Sciences. Guanajuato. MX
  • González-García, Gerardo; University of Guanajuato. Division of Natural and Exact Sciences. Guanajuato. MX
  • Báez-García, José Eduardo; University of Guanajuato. Division of Natural and Exact Sciences. Guanajuato. MX
  • Rivera-Leyva, Julio Cesar; Autonomous University of the State of Morelos. School of Pharmacy. Morelos. MX
  • Zapata-Morales, Juan Ramón; University of Guanajuato. Division of Natural and Exact Sciences. Guanajuato. MX
  • Ruiz-Padilla, Alan Joel; University of Guanajuato. Division of Natural and Exact Sciences. Guanajuato. MX
Braz. J. Pharm. Sci. (Online) ; 53(1): e16144, 2017. tab, graf
Artigo em Inglês | LILACS | ID: biblio-839453
Biblioteca responsável: BR1.1
ABSTRACT
Abstract Bioresorbable linear poly(ether-ester-urethane)s with different hydrophilic characteristics were synthesized from triblock copolymers of poly(ε-caprolactone)-poly(ethylene oxide)-poly(ε-caprolactone) (PCL-PEO) as macrodiols, and L-lysine diisocyanate (LDI) or hexamethylenediisocyanate (HDI) were used as the required diisocyanates. Macrodiols were obtained by ring-opening polymerization (ROP) of ε-caprolactone (CL). Polyurethanes were synthesized by the reaction of the triblock copolymers with LDI or HDI in solution using stannous 2-ethylhexanoate as catalyst. Polyurethane tablets were fabricated and investigated as prospective drug delivery systems. The effect of the PEO content on the polymers' performance as drug carriers was evaluated. It was found that water provoked more swelling and erosion of polymers with higher contents of PEO. The hydrocortisone release profiles were analyzed using the Ritger-Peppas approximation. An anomalous release behaviour (values of n higher than 0.5) was found for most of the analyzed samples.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Comprimidos / Hidrocortisona Idioma: Inglês Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2017 Tipo de documento: Artigo / Documento de projeto País de afiliação: México / Espanha Instituição/País de afiliação: Autonomous University of the State of Morelos/MX / Superior Council of Scientific Investigations/ES / University of Guanajuato/MX

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Comprimidos / Hidrocortisona Idioma: Inglês Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2017 Tipo de documento: Artigo / Documento de projeto País de afiliação: México / Espanha Instituição/País de afiliação: Autonomous University of the State of Morelos/MX / Superior Council of Scientific Investigations/ES / University of Guanajuato/MX
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