Pilot study of homologous platelet gel in venous ulcers
An. bras. dermatol
; 92(4): 499-504, July-Aug. 2017. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-887007
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Background:
Venous ulcers represent 70% of the lower limb ulcers. They are difficult to heal, requiring a correct diagnostic and therapeutic approach. Many products have been developed to healing, such as homologous platelet gel obtained from the platelet concentrate exceeding from blood transfusion.Objective:
To evaluate the safety and efficacy of homologous platelet gel in venous ulcers compared with hydrocolloid dressing.Method:
A pilot randomized clinical trial in patients with venous ulcers. Randomized groups (homologous platelet gel and hydrocolloid groups) were followed for 90 days and were assessed through the evolution of ulcerated area, qualitative analysis of vascularization and adverse events. Both groups used elastic compression.Results:
We included 16 participants, with a total of 21 venous ulcers. Both treatments promoted a reduction of the areas of the ulcers in 90 days (mean 69%), there was significant difference between the groups concerning the gradual reduction of the ulcers areas, favorably to the hydrocolloid (70% vs 64%; p <0.01). There were some mild adverse events in both groups. Studylimitations:
Single-center study with a small number of patients, preventing more accurate assessment of the effects of platelet gel.Conclusion:
The homologous platelet gel associated with the elastic compression can be an alternative to the venous ulcer treatment and is safe due to the occurrence of a few mild local adverse events and no serious adverse events. Clinical trials with larger numbers of patients must be performed to maintain the indication of this treatment for venous ulcer.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Úlcera Varicosa
/
Cicatrização
/
Curativos Hidrocoloides
/
Plasma Rico em Plaquetas
Tipo de estudo:
Ensaio clínico controlado
/
Estudo observacional
/
Pesquisa qualitativa
/
Fatores de risco
Limite:
Adolescente
/
Adulto
/
Humanos
Idioma:
Inglês
Revista:
An. bras. dermatol
Assunto da revista:
Dermatologia
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
São Paulo State University "Júlio de Mesquita Filho"/BR