Association between ADAM metallopeptidase domain 33 gene polymorphism and risk of childhood asthma: a meta-analysis
Braz. j. med. biol. res
; 50(10): e6148, 2017. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-888939
Biblioteca responsável:
BR1.1
ABSTRACT
This study aimed to investigate the association between ADAM metallopeptidase domain 33 (ADAM33) gene polymorphisms and the risk of childhood asthma. The relevant studies about the relationship between ADAM33 gene polymorphisms and childhood asthma were searched from electronic databases and the deadline of retrieval was May 2016. The single nucleotide polymorphisms (SNPs) of ADAM33 (rs511898, rs2280092, rs3918396, rs528557, rs2853209, rs44707, rs2280091 and rs2280089) were analyzed based on several models including the allele, codominant, recessive and dominant models. The results showed that the ADAM33 rs2280091 polymorphism in all four genetic models was associated with an increased risk of childhood asthma. Positive associations were also found between the polymorphisms rs2280090, rs2787094, rs44707 and rs528557 and childhood asthma in some genetic models. This meta-analysis suggested that ADAM33 polymorphisms rs2280091, rs2280090, rs2787094, rs44707 and rs528557 were significantly associated with a high risk of childhood asthma.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Asma
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Proteínas ADAM
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
/
Revisão sistemática
Limite:
Criança
/
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
2017
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
China
Instituição/País de afiliação:
Guangzhou Medical University/CN