determinación de bacteriocinas en muestras de consorcios microbianos nativos de ecosistemas de manglar en el departamento del atlántico, como fuente potencial de nuevos tratamientos biomédicos / The mangroves are ecosystems of high primary productivity; they are rich in organic matter and have high microbial diversity. The pressure of the physical conditions of the mangrove ecosystems has been linked to the production of special metabolites and unique molecular structures for microorganisms. Because of the developing of microbial resistance to antimicrobials in the world, it is necessary

RESUMEN

Los manglares son ecosistemas con gran diversidad microbiana; la presión de las condiciones físicas de este, se ha relacionado con la producción de metabolitos con estructuras moleculares únicas para los microorganismos. Dado el desarrollo de resistencia bacteriana a antimicrobianos a nivel mundial, se hace necesaria la búsqueda de nuevas soluciones que nos permitan contrarrestar los efectos de dichos patógenos. En este estudio, se buscó aislar, identificar y evaluar la actividad antimicrobiana de bacteriocinas producidas por microorganismos nativos del ecosistema de Manglar de la Ciénaga de Mallorquín, frente a microorganismos patógenos de interés clínico. Se comprobó actividad antimicrobiana leve del extracto CN11, CN 8, P4C3, frente a S. Aureus ATCC 25923, actividad antimicrobiana leve del extracto de P4C3 frente a E. coli BLEE, actividad antimicrobiana leve frente a Klebsiella Pneumoniae ATCC 700603 de los extractos P4C3 y CN9; y actividad antimicrobiana moderada para el caso del extracto proteico de la cepa CN9 frente a E.coli ATCC 25922

ABSTRACT

The mangroves are ecosystems of high primary productivity; they are rich in organic matter and have high microbial diversity. The pressure of the physical conditions of the mangrove ecosystems has been linked to the production of special metabolites and unique molecular structures for microorganisms. Because of the developing of microbial resistance to antimicrobials in the world, it is necessary the research of new solutions that allow to counteract the effect of those pathogens. On this study, I was looking isolate, identify and evaluate the antimicrobial bacteriocins activity produced by native microbial consortia of mangrove swamp at the Mallorquín swamp, against pathogens microorganisms of clinical interest. Mild antimicrobial activity of the extract CN11, CN 8, P4C3, was found against S. aureus ATCC 25923, mild antimicrobial activity of P4C3 extract was found against E. coli BLEE, mild antimicrobial activity of the extracts P4C3 y CN9 against Klebsiella Pneumoniae ATCC 700603; moderate antimicrobial activity for protein extract of CN9 against E. coli ATCC 25922.