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Isocryptolepine, an indoloquinoline alkaloid from Cryptolepis sanguinolenta promotes LDL uptake in HepG2 cells
Aggrey, Mike Okweesi; Li, Hui-Hui; Wang, Wen-Qiong; Song, Weibin; Wang, Yiping; Xuan, Li-Jiang.
Afiliação
  • Aggrey, Mike Okweesi; Chinese Academy of Sciences. Shanghai Institute of Materia Medica. State Key Laboratory of Drug Research. Shanghai. CN
  • Li, Hui-Hui; Chinese Academy of Sciences. Shanghai Institute of Materia Medica. State Key Laboratory of Drug Research. Shanghai. CN
  • Wang, Wen-Qiong; Chinese Academy of Sciences. Shanghai Institute of Materia Medica. State Key Laboratory of Drug Research. Shanghai. CN
  • Song, Weibin; Chinese Academy of Sciences. Shanghai Institute of Materia Medica. State Key Laboratory of Drug Research. Shanghai. CN
  • Wang, Yiping; Chinese Academy of Sciences. Shanghai Institute of Materia Medica. State Key Laboratory of Drug Research. Shanghai. CN
  • Xuan, Li-Jiang; Chinese Academy of Sciences. Shanghai Institute of Materia Medica. State Key Laboratory of Drug Research. Shanghai. CN
Rev. bras. farmacogn ; 28(6): 654-657, Nov.-Dec. 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-977750
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT About 31 percent of deaths worldwide result from atherosclerotic cardiovascular disease. Hyperlipidemia remains the major risk factor for this disease and therefore, it is necessary to identify antihyperlipidemic compounds for drug development. The crude ethanolic extract of Cryptolepis sanguinolenta (Lindl.) Schltr., Apocynaceae, has demonstrated antihyperlipidemic properties. However, the chemical constituents responsible for this action are unknown. Hence, to identify chemical constituent(s) of C. sanguinolenta with anti-hyperlipidemic effect, five indoloquinoline alkaloids were isolated and evaluated in 1,1′-dioctadecyl-3,3,3′,3′-tetramethyl-indocarbocyanine perchlorate labeled low density lipoprotein uptake assay using HepG2 cells. The minor alkaloid, isocryptolepine, showed strong activity in promoting low lipid lipoprotein uptake by 1.85-fold. Isocryptolepine may, therefore, serve as a lead compound for future studies in the development of novel antihyperlipidemic drugs.


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Tipo de estudo: Estudo prognóstico / Fatores de risco Idioma: Inglês Revista: Rev. bras. farmacogn Assunto da revista: Farmácia Ano de publicação: 2018 Tipo de documento: Artigo / Documento de projeto País de afiliação: China Instituição/País de afiliação: Chinese Academy of Sciences/CN

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Tipo de estudo: Estudo prognóstico / Fatores de risco Idioma: Inglês Revista: Rev. bras. farmacogn Assunto da revista: Farmácia Ano de publicação: 2018 Tipo de documento: Artigo / Documento de projeto País de afiliação: China Instituição/País de afiliação: Chinese Academy of Sciences/CN
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