Expression of the FUT2 gene and CD44 marker in patients with oral lesions
Inmunología (1987)
; 32(4): 123-128, oct.-dic. 2013. ilus, tab
Artigo
em Inglês
| IBECS
| ID: ibc-117490
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
The aim of this work was to investigate the FUT 2 gene, the secretor status and the expression of CD44 protein in epithelial cells obtain from saliva samples from patients with oral lesions (benign, pre-cancerous and cancerous lesions, n = 94). We analyzed polymorphisms of the FUT2 gene by allele specific oligonucleotide¨Cpolymerase chain reaction. The FUT2 gene encodes the ¦Á(1,2) fucosyltransferase (Se enzyme) that regulates the expression of ABH antigens in secretions. Generally speaking, being a non-secretor has several disadvantages with regard to metabolism and immune function. In this study, we found that oral pre-cancerous and cancerous lesions were increased among individuals with non-secretor status and nonsense mutation 428G¡úA. Fifty-one percent of the patients with oral pre-malignant and malignant lesions were non-secretors, in contrast with the healthy population (OR = 3.44). We observed a marginal association between secretor status and these lesions. Our study suggests that the lack of wild type FUT2 gene and a non-secretor status appear to be an associated risk marker for the development of oral cancer in patients with oral lesions (AU)
ABSTRACT
El objetivo del presente trabajo fue investigar la expresión del gen FUT 2 y del marcador
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Lesões Pré-Cancerosas
/
Saliva
/
Neoplasias Bucais
/
Doenças da Boca
Limite:
Humanos
Idioma:
Inglês
Revista:
Inmunología (1987)
Ano de publicação:
2013
Tipo de documento:
Artigo
Instituição/País de afiliação:
Universidad Nacional de Rosario/Argentina