Bone scintigraphy as cornerstone in the diagnosis of Erdheim-Chester disease / Papel crucial de la gammagrafía ósea en el diagnóstico de la enfermedad de ErdheimChester
Rev. esp. med. nucl. imagen mol. (Ed. impr.)
; 35(3): 193-196, mayo-jun. 2016. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-152358
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
The Erdheim-Chester disease (ECD) is an extremely rare form of non-Langerhans cell histiocytosis. The main difficulty for its diagnosis lies in the wide variety of non-specific symptoms and signs that can occur in the disease process, leading, therefore, to there being no clear-cut algorithm as a guide for an optimal biopsy to confirm the diagnosis. An 81-year-old male with history of diabetes insipidus was admitted due to non-specific respiratory signs. Imaging techniques revealed osteoblastic lesions in the lumbar spine. Whole-body bone-scintigraphy (BS) was performed, in which lesions involving the axial and appendicular skeleton, with different rates of osteoblastic activity, were observed. This highlighted a symmetrical severely intense uptake in the knees, leading to an accurate biopsy specimen that enabled making the definitive diagnosis. BS is a widely available, safe, and inexpensive technique that shows a characteristic pattern of uptake for ECD, thus its use is highly recommended for screening and guiding biopsy if clinical suspicion exists. Furthermore, when the scintigraphy pattern is incidentally observed, biopsy of increased uptake areas (tibia preferably) is mandatory in order to rule out the disease (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Cintilografia
/
Histiocitose de Células não Langerhans
/
Doença de Erdheim-Chester
Tipo de estudo:
Estudo diagnóstico
/
Guia de prática clínica
Limite:
Idoso
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. esp. med. nucl. imagen mol. (Ed. impr.)
Ano de publicação:
2016
Tipo de documento:
Artigo
Instituição/País de afiliação:
Virgen Macarena University Hospital/Spain