Previous exposure to biologics and C-reactive protein are associated with the response to tacrolimus in inflammatory bowel disease
Rev. esp. enferm. dig
; 108(9): 550-557, sept. 2016. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-156124
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Background and aims:
Inflammatory bowel disease is a chronic disorder of the gastrointestinal tract. Tacrolimus is a calcineurin inhibitor used in the prophylaxis of rejection after a solid organ transplant. There is some evidence for its use in inflammatory bowel disease, although there is a lack of information about the patients who will benefit the most with this drug and the prognostic factors for a favorable response. Material andmethods:
We performed a multicentric retrospective study evaluating all the patients who have received tacrolimus in the last 10 years as a treatment for IBD in our area.Results:
A total of 20 patients, 12 with Crohns disease and 8 with ulcerative colitis, were included in four hospitals. The two most common indications were steroid-dependency and fistulizing Crohns disease. The median time receiving tacrolimus was 11 months. In 12 patients the treatment was stopped. The main reasons for drug withdrawal were absence or loss of response. The median clinical follow-up was 35.5 months. Overall, a 25% achieved clinical remission and 40% were in partial response. Biologic-naïve patients demonstrated a significantly better remission rate as compared with those that were not (80 vs. 7%). Patients who achieved remission were more likely to have a significant reduction in C-reactive protein values 1 month after starting the drug. Seven patients required surgery during the follow- up period.Conclusions:
Patients naïve to biologics showed a significantly better response to tacrolimus. A reduction in C-reactive protein one month after starting this drug was associated with clinical remission(AU)RESUMEN
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Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Proteína C-Reativa
/
Doenças Inflamatórias Intestinais
/
Tacrolimo
Tipo de estudo:
Ensaio clínico controlado
/
Estudo observacional
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Estudo prognóstico
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Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. esp. enferm. dig
Ano de publicação:
2016
Tipo de documento:
Artigo
Instituição/País de afiliação:
Complejo Hospitalario de Navarra/Spain
/
Hospital Universitario de Basurto/Spain
/
Hospital Universitario de Cruces/Spain
/
Hospital de Galdakao/Spain