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Correlation between serological biomarkers and endoscopic activity in patients with inflammatory bowel disease / Correlación entre los marcadores biológicos y la actividad endoscópica en pacientes con enfermedad inflamatoria intestinal
Miranda-García, Pablo; Chaparro, María; Gisbert, Javier P.
Afiliação
  • Miranda-García, Pablo; Hospital Universitario Quirón. Gastroenterology Department. Madrid. Spain
  • Chaparro, María; Hospital Universitario La Princesa. Gastroenterology Department. Instituto de Investigación Sanitaria Princesa (IIS-IP). Madrid. Spain
  • Gisbert, Javier P; Hospital Universitario La Princesa. Gastroenterology Department. Instituto de Investigación Sanitaria Princesa (IIS-IP). Madrid. Spain
Gastroenterol. hepatol. (Ed. impr.) ; 39(8): 508-515, oct. 2016. tab, graf
Artigo em Inglês | IBECS | ID: ibc-156237
Biblioteca responsável: ES1.1
Localização: BNCS
RESUMEN
BACKGROUND/

AIMS:

Endoscopy is the gold standard for assessing disease severity in inflammatory bowel disease (IBD), although it is an invasive procedure. Biological markers have been routinely used as a non-invasive means of determining disease activity. The aim of this study was to determine the correlation between common biological markers and endoscopic activity in IBD.

METHODS:

Consecutive patients with IBD were included. Serum concentrations of different biomarkers (C-reactive protein [CRP], orosomucoid [ORM], erythrocyte sedimentation rate [ESR], fibrinogen, platelets, leukocytes, neutrophils and hemoglobin [Hb]) were measured, and their accuracy in detecting endoscopic activity was determined.

RESULTS:

Eighty patients were included (mean age 46 years, 53% Crohn's disease), 70% with endoscopic activity. Among Crohn's disease patients, 24% had mild endoscopic activity, 12% moderate activity and 39% severe activity. Among ulcerative colitis patients, 35% had an endoscopic Mayo score of 0-1 points, 30% 2 points and 35% 3 points. None of the biomarkers included had a good correlation with endoscopic activity (Area Under the ROC curve [AUC] < 0.70) in ulcerative colitis. ORM, fibrinogen and platelets had the best accuracy to detect endoscopic activity in Crohn's disease (AUC 0.80-0.085). A sub-analysis in postoperative Crohn's disease patients found no correlation between endoscopic recurrence and biomarkers (AUC < 0.70).

CONCLUSIONS:

Serological biomarkers, including CRP, have low accuracy to detect endoscopic activity in ulcerative colitis and postoperative Crohn's disease. ORM, fibrinogen and platelets have the best accuracy to detect endoscopic activity in Crohn's disease
Assuntos

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Doenças Inflamatórias Intestinais / Colite Ulcerativa / Doença de Crohn Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Gastroenterol. hepatol. (Ed. impr.) Ano de publicação: 2016 Tipo de documento: Artigo Instituição/País de afiliação: Hospital Universitario La Princesa/Spain / Hospital Universitario Quirón/Spain

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Doenças Inflamatórias Intestinais / Colite Ulcerativa / Doença de Crohn Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Gastroenterol. hepatol. (Ed. impr.) Ano de publicação: 2016 Tipo de documento: Artigo Instituição/País de afiliação: Hospital Universitario La Princesa/Spain / Hospital Universitario Quirón/Spain
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