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A novel capillary nano-immunoassay for assessing androgen receptor splice variant 7 in plasma. Correlation with CD133 antigen expression in circulating tumor cells. A pilot study in prostate cancer patients
García, JL; Lozano, R; Misiewicz-Krzeminska, I; Fernández-Mateos, J; Krzeminski, P; Alfonso, S; Marcos, RA; García, R; Gómez-Veiga, F; Virseda, Á; Herrero, M; Olmos, D; Cruz-Hernández, JJ.
Afiliação
  • García, JL; Institute of Biomedical Research of Salamanca (IBSAL). Salamanca. Spain
  • Lozano, R; Hospital Universitario de Salamanca. Medical Oncology Service. Salamanca. Spain
  • Misiewicz-Krzeminska, I; Institute of Biomedical Research of Salamanca (IBSAL). Salamanca. Spain
  • Fernández-Mateos, J; Hospital Universitario de Salamanca. Medical Oncology Service. Salamanca. Spain
  • Krzeminski, P; Institute of Biomedical Research of Salamanca (IBSAL). Salamanca. Spain
  • Alfonso, S; Hospital Universitario de Salamanca. Medical Oncology Service. Salamanca. Spain
  • Marcos, RA; Complejo Asistencial Nuestra Señora de Sonsoles. Departamento de Oncología Médica. Ávila. Spain
  • García, R; Hospital Universitario de Salamanca. Medical Oncology Service. Salamanca. Spain
  • Gómez-Veiga, F; Hospital Universitario de Salamanca. Urology Department. Salamanca. Spain
  • Virseda, Á; Hospital Universitario de Salamanca. Urology Department. Salamanca. Spain
  • Herrero, M; Hospital Universitario de Salamanca. Urology Department. Salamanca. Spain
  • Olmos, D; Spanish National Cancer Research Centre (CNIO). Prostate Cancer Clinical Research Unit. Madrid. Spain
  • Cruz-Hernández, JJ; Hospital Universitario de Salamanca. Medical Oncology Service. Salamanca. Spain
Clin. transl. oncol. (Print) ; 19(11): 1350-1357, nov. 2017. tab, ilus, graf
Artigo em Inglês | IBECS | ID: ibc-167116
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
Purpose. Androgen receptor (AR) splice variant 7 (AR-V7) has been related with both a higher risk of prostate cancer (PC) progression and differential responsiveness to hormonal agents versus chemotherapy. The objective of this study was to investigate the feasibility of a novel capillary nano-immunoassay in assessing AR-V7 in plasma from PC patients. Methods. Patients with either localized or advanced PC were included in the study. Assessment of AR-V7 in plasma was performed through a capillary nano-immunoassay platform. Correlation with clinical data, stem cell biomarkers (such as CD133+), AR amplification and PTEN status was identified. Results. The study included 72 PC patients. AR-V7 signal was detected in 21 (29%) patients 17 (81%) had a Gleason score ≥7, 15 (71%) castration-resistant prostate cancer (CRPC), 18 (86%) metastatic disease and PSA (median) high than AR-V7 negative (p < 0.05). CD133 was expressed in 69 (96%) patients. The median CD133+ expression in circulating tumor cells CTCs was higher among the 21 AR-V7 positive cases versus AR-V7 negative (7 vs. 3). Androgen Receptor and PTEN fluorescence in situ hybridization (FISH) on CD133+ captured cells were performed 37 cases showed ≥four CD133+ CTCs, of which 81% showed an increased AR copy number. This percentage was similar in both AR-V7-positive and AR-V7-negative patients. A total of 68% of the cases showed deletion of PTEN 70% were ARV-7 positive vs. 67%, which were AR-V7 negative. Conclusions. Assessing the presence of AR-V7 in plasma from PC patients is feasible by a novel capillary nano-immunoassay. AR-V7 was observed in 29% of the tumors and is more frequent in aggressive tumors (AU)
RESUMEN
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Neoplasias da Próstata / Receptores Androgênicos / Neoplasias de Próstata Resistentes à Castração / Células Neoplásicas Circulantes Tipo de estudo: Estudo prognóstico Limite: Humanos / Masculino Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2017 Tipo de documento: Artigo Instituição/País de afiliação: Complejo Asistencial Nuestra Señora de Sonsoles/Spain / Hospital Universitario de Salamanca/Spain / Institute of Biomedical Research of Salamanca (IBSAL)/Spain / Spanish National Cancer Research Centre (CNIO)/Spain
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Neoplasias da Próstata / Receptores Androgênicos / Neoplasias de Próstata Resistentes à Castração / Células Neoplásicas Circulantes Tipo de estudo: Estudo prognóstico Limite: Humanos / Masculino Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2017 Tipo de documento: Artigo Instituição/País de afiliação: Complejo Asistencial Nuestra Señora de Sonsoles/Spain / Hospital Universitario de Salamanca/Spain / Institute of Biomedical Research of Salamanca (IBSAL)/Spain / Spanish National Cancer Research Centre (CNIO)/Spain
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