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Ki67 targeted strategies for cancer therapy
Yang, C; Zhang, J; Ding, M; Xu, K; Li, L; Mao, L; Zheng, J.
Afiliação
  • Yang, C; Xuzhou Medical University. Jiangsu Key Laboratory of Biological Cancer Therapy. Xuzhou. China
  • Zhang, J; Xuzhou Medical University. Jiangsu Key Laboratory of Biological Cancer Therapy. Xuzhou. China
  • Ding, M; Xuzhou Medical University. Jiangsu Key Laboratory of Biological Cancer Therapy. Xuzhou. China
  • Xu, K; Xuzhou Medical University. Jiangsu Key Laboratory of Biological Cancer Therapy. Xuzhou. China
  • Li, L; Xuzhou Medical University. Jiangsu Key Laboratory of Biological Cancer Therapy. Xuzhou. China
  • Mao, L; Xuzhou Medical University. Jiangsu Key Laboratory of Biological Cancer Therapy. Xuzhou. China
  • Zheng, J; Xuzhou Medical University. Jiangsu Key Laboratory of Biological Cancer Therapy. Xuzhou. China
Clin. transl. oncol. (Print) ; 20(5): 570-575, mayo 2018. ilus
Artigo em Inglês | IBECS | ID: ibc-173532
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
Ki67 is a well-known proliferation marker for the evaluation of cell proliferation. Numerous studies have indicated that Ki67 index independently predicts cancer progression. Moreover, because Ki67 is highly expressed in malignant cells but almost could not be detected in normal cells, it has become a promising target for cancer therapy. In this review, we summarize recent advances in Ki67 targeted cancer therapy. In particular, we highlight recent development on the exploitation of Ki67 promoter to drive the expression of siRNAs or therapeutic genes in cancer cells specifically. The use of Ki67 as an attractive target opens a new avenue for cancer therapy
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Prognóstico / Radioterapia / Terapia Genética / Proliferação de Células / Neoplasias Renais Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: Xuzhou Medical University/China
Buscar no Google
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Prognóstico / Radioterapia / Terapia Genética / Proliferação de Células / Neoplasias Renais Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: Xuzhou Medical University/China