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Delay in starting radiotherapy due to neoadjuvant therapy does not worsen survival in unresected glioblastoma patients
Balaña, C; Estival, A; Teruel, I; Hardy-Werbin, M; Sepulveda, J; Pineda, E; Martinez-García, M; Gallego, O; Luque, R; Gil-Gil, M; Mesia, C; Barco, S del; Herrero, A; Berrocal, A; Perez-Segura, P; Penas, R de las; Marruecos, J; Fuentes, R; Reynes, G; Velarde, JM; Cardona, A; Verger, E; Panciroli, C; Villà, S.
Afiliação
  • Balaña, C; Hospital Universitari Germans Trias i Pujol. Medical Oncology Service. Badalona. Spain
  • Estival, A; Hospital Universitari Germans Trias i Pujol. Medical Oncology Service. Badalona. Spain
  • Teruel, I; Hospital Universitari Germans Trias i Pujol. Medical Oncology Service. Badalona. Spain
  • Hardy-Werbin, M; Hospital del Mar Medical Research Institute (IMIM). Cancer Research Programm. Barcelona. Spain
  • Sepulveda, J; Hospital Universitario. Medical Oncology Service. Madrid. Spain
  • Pineda, E; Hospital Clinic Provincial. Medical Oncology Service. Barcelona. Spain
  • Martinez-García, M; Hospital del Mar. Medical Oncology Service. Barcelona. Spain
  • Gallego, O; Hospital de Sant Pau. Medical Oncology Service. Barcelona. Spain
  • Luque, R; Hospital Universitario Virgen de las Nieves. Medical Oncology Service. Granada. Spain
  • Gil-Gil, M; Institut Català d’Oncologia. Medical Oncology Service. Hospitalet de Llobregat. Spain
  • Mesia, C; Institut Català d’Oncologia. Medical Oncology Service. Hospitalet de Llobregat. Spain
  • Barco, S del; Hospital Josep Trueta. Medical Oncology Service. Girona. Spain
  • Herrero, A; Hospital Miguel Servet. Medical Oncology Service. Saragossa. Spain
  • Berrocal, A; Hospital General Universitario de Valencia. Medical Oncology Service. Valencia. Spain
  • Perez-Segura, P; Hospital Universitario Clínico San Carlos. Medical Oncology Service. Madrid. Spain
  • Penas, R de las; Hospital Provincial de Castellón. Medical Oncology Service. Castellón. Spain
  • Marruecos, J; Hospital Josep Trueta. Radiation Oncology Service. Girona. Spain
  • Fuentes, R; Hospital Josep Trueta. Radiation Oncology Service. Girona. Spain
  • Reynes, G; Hospital Universitario La Fe. Medical Oncology Service. Valencia. Spain
  • Velarde, JM; Hospital Germans Trias i Pujol. Institut Investigació Germans Trias i Pujol (IGTP). Badalona. Spain
  • Cardona, A; Clínica del Country. Clinical and Translational Oncology Group. Bogotá. Colombia
  • Verger, E; Hospital Clinic Provincial. Radiation Oncology Service. Barcelona. Spain
  • Panciroli, C; Hospital Germans Trias i Pujol. Institut Investigació Germans Trias i Pujol (IGTP). Badalona. Spain
  • Villà, S; Hospital Universitari Germans Trias i Pujol. Radiation Oncology Service. Badalona. Spain
Clin. transl. oncol. (Print) ; 20(12): 1529-1537, dic. 2018. tab
Artigo em Inglês | IBECS | ID: ibc-173759
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

Purpose:

We retrospectively examined the potential effect on overall survival (OS) of delaying radiotherapy to administer neoadjuvant therapy in unresected glioblastoma patients. Patients and

methods:

We compared OS in 119 patients receiving neoadjuvant therapy followed by standard treatment (NA group) and 96 patients receiving standard treatment without neoadjuvant therapy (NoNA group). The MaxStat package of R identified the optimal cut-off point for waiting time to radiotherapy.

Results:

OS was similar in the NA and NoNA groups. Median waiting time to radiotherapy after surgery was 13 weeks for the NA group and 4.2 weeks for the NoNA group. The longest OS was attained by patients who started radiotherapy after 12 weeks and the shortest by patients who started radiotherapy within 4 weeks (12.3 vs 6.6 months) (P = 0.05). OS was 6.6 months for patients who started radiotherapy before the optimal cutoff of 6.43 weeks and 19.1 months for those who started after this time (P = 0.005). Patients who completed radiotherapy had longer OS than those who did not, in all 215 patients and in the NA and NoNA groups (P = 0.000). In several multivariate analyses, completing radiotherapy was a universally favorable prognostic factor, while neoadjuvant therapy was never identified as a negative prognostic factor.

Conclusion:

In our series of unresected patients receiving neoadjuvant treatment, in spite of the delay in starting radiotherapy, OS was not inferior to that of a similar group of patients with no delay in starting radiotherapy
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Radioterapia / Glioblastoma / Terapia Neoadjuvante Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: Clínica del Country/Colombia / Hospital Clinic Provincial/Spain / Hospital General Universitario de Valencia/Spain / Hospital Germans Trias i Pujol/Spain / Hospital Josep Trueta/Spain / Hospital Miguel Servet/Spain / Hospital Provincial de Castellón/Spain / Hospital Universitari Germans Trias i Pujol/Spain / Hospital Universitario Clínico San Carlos/Spain / Hospital Universitario La Fe/Spain
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Radioterapia / Glioblastoma / Terapia Neoadjuvante Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Clin. transl. oncol. (Print) Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: Clínica del Country/Colombia / Hospital Clinic Provincial/Spain / Hospital General Universitario de Valencia/Spain / Hospital Germans Trias i Pujol/Spain / Hospital Josep Trueta/Spain / Hospital Miguel Servet/Spain / Hospital Provincial de Castellón/Spain / Hospital Universitari Germans Trias i Pujol/Spain / Hospital Universitario Clínico San Carlos/Spain / Hospital Universitario La Fe/Spain
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