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Diez años de seguimiento de la cohorte española del estudio Europeo PreventCD: lecciones aprendidas / Ten years of follow-up of the Spanish cohort of the European PreventCD study: the lessons learned
Crespo Escobar, Paula; Castillejo, Gemma; Martínez-Ojinaga, Eva; Donat, Ester; Polanco, Isabel; Mearin, María Luisa; Ribes-Koninckx, Carmen.
Afiliação
  • Crespo Escobar, Paula; Instituto de Investigación Sanitaria La Fe. Unidad de Enfermedad Celiaca e Inmunopatología Digestiva. Valencia. España
  • Castillejo, Gemma; Hospital Universitari Sant Joan. Reus. España
  • Martínez-Ojinaga, Eva; Hospital Universitario La Paz. Departamento de Gastroenterología y Nutrición Pediátrica. Madrid. España
  • Donat, Ester; Hospital Universitari i Politècnic La Fe. Departamento de Gastroenterología Pediátrica. Valencia. España
  • Polanco, Isabel; Hospital Universitario La Paz. Departamento de Gastroenterología y Nutrición Pediátrica. Madrid. España
  • Mearin, María Luisa; Leiden University Medical Centre. Department of Pediatrics. Leiden. Netherlands
  • Ribes-Koninckx, Carmen; Hospital Universitari i Politècnic La Fe. Departamento de Gastroenterología Pediátrica. Valencia. España
Rev. esp. enferm. dig ; 110(8): 493-499, ago. 2018. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-177758
Biblioteca responsável: ES1.1
Localização: BNCS
RESUMEN

Objetivo:

evaluar la influencia del consumo de gluten en el desarrollo de enfermedad celiaca y describir la historia natural de la misma, en una cohorte española de riesgo genético participante en el estudio Europeo PreventCD.

Métodos:

estudio prospectivo multicéntrico doble ciego, incluyendo 225 niños, controlados desde el nacimiento, en tres centros de Madrid, Reus y Valencia, todos HLA-DQ2/HLA-DQ8 positivos y con un familiar de primer grado con enfermedad celiaca. Entre cuatro y diez meses, la ingesta de gluten estaba pautada por protocolo. Entre los 11-36 meses, la ingesta fue libre, siendo cuantificada prospectivamente mediante registros dietéticos. Se realizaron visitas clínicas y análisis de anticuerpos específicos de enfermedad celiaca periódicamente.

Conclusiones:

ni la cantidad de gluten consumida entre los 11 y los 36 meses ni la duración de la lactancia son factores de riesgo de desarrollo de EC en la población española, siendo el genotipo HLA y el sexo los factores más relevantes asociados a la misma. En este grupo de riesgo, la mayoría de casos debutaron antes de los dos años, encontrándose a esta temprana edad pacientes con escasa expresividad clínica
ABSTRACT

Aim:

to evaluate the influence of gluten consumption on celiac disease development and to describe its natural history in the Spanish cohort of the European PreventCD study.

Methods:

prospective multi-center double blind study of 225 children that were followed up from birth. All cases were HLA-DQ2/HLA-DQ8 positive with a 1st degree relative with celiac disease and were followed up in three centers from Madrid, Reus and Valencia. Gluten intake was determined between four and ten months according to the protocol. Gluten intake was ad libitum between eleven and 36 months and was prospectively quantified by means of dietary records. Clinical visits and specific antibody analysis for celiac disease were performed periodically.

Results:

twenty-six cases were diagnosed, all had a positive biopsy and serology; 21 had gastrointestinal symptoms and five were asymptomatic. In addition, 2,565 food records were analyzed and statistically significant differences (p < 0.001) were found with regard to gluten consumption among the three centers, although not between celiac and non-celiac children (p = 0.025). The HLA-DQ2.5/DQ2.5 and DQ2.5/DQ2.2 genotypes had a relative risk of 4.7 (95% CI 0.80-27.55; p = 0.08), which was higher than for the rest of genotypes. Female gender also had a relative risk that was five times higher than that for males.

Conclusions:

the amount of gluten intake between 11 and 36 months or the duration of breast feeding were not risk factors for the development of CD in the Spanish population. The HLA genotype and gender were the most relevant associated factors. In this at-risk group, the disease presented before two years of age in the majority of the cases with a weak clinical expression
Assuntos

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Doença Celíaca / Dieta Livre de Glúten / Glutens Limite: Criança / Criança, pré-escolar / Feminino / Humanos / Lactente / Masculino Idioma: Espanhol Revista: Rev. esp. enferm. dig Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: Hospital Universitari Sant Joan/España / Hospital Universitari i Politècnic La Fe/España / Hospital Universitario La Paz/España / Instituto de Investigación Sanitaria La Fe/España / Leiden University Medical Centre/Netherlands

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Doença Celíaca / Dieta Livre de Glúten / Glutens Limite: Criança / Criança, pré-escolar / Feminino / Humanos / Lactente / Masculino Idioma: Espanhol Revista: Rev. esp. enferm. dig Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: Hospital Universitari Sant Joan/España / Hospital Universitari i Politècnic La Fe/España / Hospital Universitario La Paz/España / Instituto de Investigación Sanitaria La Fe/España / Leiden University Medical Centre/Netherlands
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