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The relationship between adiposopathy and glucose-insulin homeostasis is not affected by moderate-intensity aerobic training in healthy women with obesity
Clément, Andrée-Anne; Riesco, Eléonor; Tessier, Sébastien; Lacaille, Michel; Pérusse, Francine; Coté, Mélanie; Després, Jean-Pierre; Weisnagel, John; Doré, Jean; Joanisse, Denis R; Mauriège, Pascale.
Afiliação
  • Clément, Andrée-Anne; Laval University. Faculty of Medicine. Department of Kinesiology. Québec. Canada
  • Riesco, Eléonor; University of Sherbrooke. Faculty of Physical Activity Sciences. Sherbrooke. Canada
  • Tessier, Sébastien; Institut National de Santé Publique. Québec. Canada
  • Lacaille, Michel; Québec Heart and Lung University Research Centre. Québec. Canada
  • Pérusse, Francine; Laval University. Faculty of Medicine. Department of Kinesiology. Québec. Canada
  • Coté, Mélanie; Québec Heart and Lung University Research Centre. Québec. Canada
  • Després, Jean-Pierre; Laval University. Faculty of Medicine. Department of Kinesiology. Québec. Canada
  • Weisnagel, John; Centre Hospitalier de l’Université Laval (CHUL). Diabetes Research Unit. Québec. Canada
  • Doré, Jean; Laval University. Faculty of Medicine. Department of Kinesiology. Québec. Canada
  • Joanisse, Denis R; Laval University. Faculty of Medicine. Department of Kinesiology. Québec. Canada
  • Mauriège, Pascale; Laval University. Faculty of Medicine. Department of Kinesiology. Québec. Canada
J. physiol. biochem ; 74(4): 591-601, nov. 2018. tab, graf
Artigo em Inglês | IBECS | ID: ibc-179037
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
The contribution of adiposopathy to glucose-insulin homeostasis remains unclear. This longitudinal study examined the potential relationship between the adiponectin/leptin ratio (A/L, a marker of adiposopathy) and insulin resistance (IR homeostasis model assessment (HOMA)), insulin sensitivity (IS Matsuda), and insulin response to an oral glucose tolerance test before and after a 16-week walking program, in 29 physically inactive pre- and postmenopausal women with obesity (BMI, 29-35 kg/m2; age, 47-54 years). Anthropometry, body composition, VO2max, and fasting lipid-lipoprotein and inflammatory profiles were assessed. A/L was unchanged after training (p = 0.15), despite decreased leptin levels (p < 0.05). While the Matsuda index tended to increase (p = 0.07), HOMA decreased (p < 0.05) and fasting insulin was reduced (p < 0.01) but insulin area under the curve (AUC) remained unchanged (p = 0.18) after training. Body fatness and VO2max were improved (p < 0.05) while triacylglycerols increased and HDL-CHOL levels decreased after training (p < 0.05). At baseline, A/L was positively associated with VO2max, HDL-CHOL levels, and Matsuda (0.37 < ρ < 0.56; p < 0.05) but negatively with body fatness, HOMA, insulin AUC, IL-6, and hs-CRP levels (− 0.41 < ρ < − 0.66; p < 0.05). After training, associations with fitness, HOMA, and inflammation were lost. Multiple regression analysis revealed A/L as an independent predictor of IR and IS, before training (partial R2 = 0.10 and 0.22), although A/L did not predict the insulin AUC pre- or post-intervention. A significant correlation was found between training-induced changes to A/L and IS (r = 0.38; p < 0.05) but not with IR or insulin AUC. Although changes in the A/L ratio could not explain improvements to glucose-insulin homeostasis indices following training, a relationship with insulin sensitivity was revealed in healthy women with obesity
Assuntos
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Resistência à Insulina / Saúde da População Urbana / Leptina / Adiponectina / Adiposidade / Condicionamento Físico Humano / Obesidade Metabolicamente Benigna Limite: Feminino / Humanos Idioma: Inglês Revista: J. physiol. biochem Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: Centre Hospitalier de l’Université Laval (CHUL)/Canada / Institut National de Santé Publique/Canada / Laval University/Canada / Québec Heart and Lung University Research Centre/Canada / University of Sherbrooke/Canada
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Resistência à Insulina / Saúde da População Urbana / Leptina / Adiponectina / Adiposidade / Condicionamento Físico Humano / Obesidade Metabolicamente Benigna Limite: Feminino / Humanos Idioma: Inglês Revista: J. physiol. biochem Ano de publicação: 2018 Tipo de documento: Artigo Instituição/País de afiliação: Centre Hospitalier de l’Université Laval (CHUL)/Canada / Institut National de Santé Publique/Canada / Laval University/Canada / Québec Heart and Lung University Research Centre/Canada / University of Sherbrooke/Canada
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