Analgesic efficacy of ketorolac associated with a tramadol/acetaminophen combination after third molar surgery - a randomized, triple-blind clinical trial
Med. oral patol. oral cir. bucal (Internet)
; 24(1): e85-e102, ene. 2019. graf, tab
Artigo
em Inglês
| IBECS
| ID: ibc-180412
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Background:
This study compared the efficacy of ketorolac alone versus its combination with tramadol/acetaminophen for pain control after mandibular third molar surgery. Material andMethods:
A randomized, triple-blind clinical trial was carried out with 52 patients divided into 2 groups Group K+T+A (1 tablet of Ketorolac 10 mg plus and 1 capsule of Tramadol 37.5 mg/acetaminophen 325 mg) and Group K (1 tablet of Ketorolac 10 mg plus and 1 placebo capsule). The treatments were given 1 h before the surgery and was repeated 4 times per day, for 48 h. The difference in postoperative pain was assessed by 4 primary end-points pain intensity (VAS 100mm, for 48 h), rescue medication, overall assessment and adverse effects.Results:
Significant differences in pain intensity were observed in the different times (p < 0.05). The comparison of groups in each time showed significant differences only of 9 h, with lower level of pain intensity for group K+T+A (p = 0.005). The need of analgesics was higher in Group K (p < 0.001), the need of antiemetic were greater in Group K+T+A (p < 0.0001). No significant difference between groups were observed in overall assessment. The adverse effects was higher in Group K+T+A.Conclusions:
The current study showed that both ketorolac and the combination of ketorolac plus tramadol/acetaminophen showed good control of pain after the extraction of the lower third molars. Although the combination group showed lower pain at 9 h, the difference is small and not clinically relevantRESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Dor Pós-Operatória
/
Tramadol
/
Cetorolaco
/
Manejo da Dor
/
Acetaminofen
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2019
Tipo de documento:
Artigo
Instituição/País de afiliação:
State University of Ponta Grossa/Brazil