Tratamento ambulatorial de rejeiçäo persistente com methotrexate em pacientes submetidos a transplante cardíaco estáveis clinicamente / Treatment of persistent rejection with methotrexate in stable patients submmitted to heart transplantation
Arq. bras. cardiol
; 74(2): 141-8, Jan. 2000. tab, graf
Artigo
em Português, Inglês
| LILACS
| ID: lil-262347
Biblioteca responsável:
BR1.1
ABSTRACT
OBJECTIVE:
To evaluate the use of methotrexate for the treatment of recurrent rejection in heart transplant recipients.METHODS:
We studied 6 patients submitted to heart transplantation that showed rejection grade ü 3A (ISHLT) in two consecutives endomyocardial biopsy specimens. The dose was 11.26ñ3.75mg/week. The evaluated data were ventricular function, endomyocardial biopsy, white cell count and number of rejection episodes before and after methotrexate administration.RESULTS:
There was a reduction in the number of rejection episodes (5.17ñ1.47 before methotrexate; 2.33ñ1.75 after 6 months and 3.17ñ2.99 after 12 months of treatment, p=0.0193). The ventricular function was normal with ejection fraction of 76.5ñ4.80 before and 75.6ñ4.59 after methotrexate (p=0.4859). One patient did not finish the treatment because he showed signs of rejection associated with severe pericardial effusion. Five patients had a reduction in the white cell count (8,108ñ23.72 before and 5650ñ1350 after methotrexate, p=0.0961). One pulmonary infection with complete resolution after antibiotic treatment was observed.CONCLUSION:
Methotrexate in low doses is an effective adjunct therapy in the treatment of recurrent rejection after heart transplantation.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Metotrexato
/
Transplante de Coração
/
Assistência Ambulatorial
/
Rejeição de Enxerto
/
Imunossupressores
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
/
Português
Revista:
Arq. bras. cardiol
Assunto da revista:
Cardiologia
Ano de publicação:
2000
Tipo de documento:
Artigo