Cardiac damage from chronic use of chloroquine: a case report and review of the literature
Arq. bras. cardiol
; 79(1): 85-88, July 2002. ilus
Artigo
em Inglês
| LILACS
| ID: lil-316169
Biblioteca responsável:
BR1.1
RESUMO
Chloroquine has been widely used in rheumatological treatment, but potential severe side effects require careful follow-up. Cardiac damage is not a common consequence, but its clinical relevance has not yet been described. We report the case of a 58-year-old woman with rheumatoid arthritis, in whom chronic chloroquine use resulted in major irreversible cardiac damage. She presented with syncopal episodes due to complete atrioventricular block confirmed by electrophysiological study whose changes were concluded to be irreversible and a permanent pacemaker was indicated. Endomyocardial biopsy was also performed to search for histopathological and ultrastructural cardiac damage. We also reviewed the 22 cases of chloroquine-induced cardiopathy described to date as well as its pathophysiology
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Cloroquina
/
Cardiopatias
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Arq. bras. cardiol
Assunto da revista:
Cardiologia
Ano de publicação:
2002
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
University of Säo Paulo/BR