Avaliação da eficácia e segurança do etofibrato em pacientes dislipidêmicos. Estudo multicêntrico / Evaluation of efficacy and safety of etofibrate in primary hyperlipidemia. A multicenter study
Arq. bras. cardiol
; 67(6): 419-422, Dez. 1996. tab
Artigo
em Português
| LILACS
| ID: lil-319218
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE:
To evaluate the clinical efficacy of etofibrate in primary hyperlipidemia in patients from clinical centers representative of all main Brazilian cities.METHODS:
One thousand, nine hundred and fourty three hyperlipidemic patients were submitted to diet and drug treatment with etofibrate (500 mg/day) for eight weeks. The data b WAS analyzed as to changes in the lipoprotein profile, as well as the side effects.RESULTS:
There was an important reduction in total cholesterol (19.88), triglycerides (29.59), LDL-c (14.89) and VLDL-c (14.54) concentration. There was a significant increase in HDL-c (18.14). Adverse effects were observed in 8.5 of the patients, without major clinical relevance, however, in 1.44 the treatment had to be interrupted.CONCLUSION:
Administration of etofibrate promoted positive changes in all parameters of the lipid and lipoprotein profile, thus reducing the risk of atherosclerotic disease, without significant side effects in the great majority of sample studied.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Ácido Clofíbrico
/
Hiperlipidemias
/
Hipolipemiantes
Tipo de estudo:
Ensaio clínico controlado
Limite:
Adolescente
/
Adulto
/
Idoso, 80 anos ou mais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Português
Revista:
Arq. bras. cardiol
Assunto da revista:
Cardiologia
Ano de publicação:
1996
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Faculdade de Medicina de Ribeirão Preto-USP. Escola Paulista de Medicina (UNIFESP)/BR