Toxicidad sub-crónica y prueba de irritabilidad ocular del extracto acuoso de las hojas de Plantago major (Plantaginaceae) / Sub-chronic toxicity and test of eye irritability of leaf aqueous extract from Plantago major (plantaginaceae)
Rev. biol. trop
; 51(3/4): 635-638, sept.-dic. 2003.
Artigo
em Espanhol
| LILACS
| ID: lil-365902
Biblioteca responsável:
BR1.1
ABSTRACT
For the sub-chronic toxicity an aqueous preparation of Plantago major leaves was tested in 20 male NGP mice, with an average weight of 20.15 g and separated in two groups of ten individuals each. The dose used was 2000 mg/kg and the control group received 0.5 ml of distilled water. The extract administration was done daily during five days at week for a total period of 40 days. Signs of sub-chronic toxicity were observed in the days two and 12 of treatment. No significant change in corporal weight was observed. The ocular irritation was tested in five New Zeland male rabbits, with an average weight of 3.640 kg. The dose used was a 200 microliters the preparation (100 mg/ml) of Plantago major leaves, instill into the right eye and the control was used the left eye instill 200 microliters of distilled water. The administration was done daily during five days. The extract shows no significant irritation during the observation period.
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Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Plantago
/
Testes de Toxicidade Crônica
/
Olho
Limite:
Animais
Idioma:
Espanhol
Revista:
Rev. biol. trop
Assunto da revista:
Biologia
/
Medicina Tropical
Ano de publicação:
2003
Tipo de documento:
Artigo
País de afiliação:
Costa Rica
Instituição/País de afiliação:
Universidad de Costa Rica/CR