Hepatitis C in hemodialysis: the contribution of injection drug use
Braz. j. infect. dis
; 14(4): 422-426, July-Aug. 2010. tab
Artigo
em Inglês
| LILACS
| ID: lil-561219
Biblioteca responsável:
BR1.1
ABSTRACT
BACKGROUND:
Hepatitis C virus (HCV) infection is the most common cause of acute or chronic hepatitis in patients on hemodialysis (HD). The purpose of this study was to describe the prevalence of positive HCV RNA and investigate injection drug use as an emerging risk factor in patients with chronic renal disease on HD.METHODS:
This was a multicenter cross-sectional study with 325 patients with chronic renal disease on HD in the period between August 1, 2005 to August 30, 2006, receiving care at four institutions in the city of Porto Alegre, Southern Brazil. Epidemiological data were collected by means of a structured questionnaire. The following laboratory tests were performed alanine aminotransferase (ALT), anti-hepatitis C virus antibodies (anti-HCV), and qualitative polymerase chain reaction (PCR).RESULTS:
Of 325 patients, 68 had positive HCV RNA results. The comparison between patients with positive and negative PCR results revealed significant differences in duration of HD (mean = 71 versus 52.4 months; p = 0.02); previous blood transfusion (92 percent versus 72 percent; p < 0.01); injection drug use (13 percent versus 0.7 percent; p < 0.01); anti-HCV positivity at start of HD therapy (60 percent versus 4 percent; p < 0.01); and mean ALT value (39 versus 26.5; p < 0.01). Logistic regression analysis showed a positive HCV RNA independently associated to being on HD for more than five years [OR 2.1 (95 percent CI 1.2 -3.8)]; previous blood transfusion [OR 3.7 (95 percent CI 1.4 - 9.5)]; and injection drug use [OR 22.6 (95 percent CI 4.2 - 119.6)].CONCLUSION:
Injection drug use was an independent risk factor for HCV infection among chronic renal disease patients on HD.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.5 Prevenção e tratamento do consumo de substâncias psicoativas
Base de dados:
LILACS
Assunto principal:
RNA Viral
/
Diálise Renal
/
Hepatite C
/
Anticorpos Anti-Hepatite C
/
Transtornos Relacionados ao Uso de Substâncias
/
Alanina Transaminase
Tipo de estudo:
Ensaio clínico controlado
/
Estudo diagnóstico
/
Estudo de etiologia
/
Estudo observacional
/
Estudo de prevalência
/
Pesquisa qualitativa
/
Fatores de risco
Limite:
Adulto
/
Idoso
/
Idoso, 80 anos ou mais
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2010
Tipo de documento:
Artigo