Your browser doesn't support javascript.
loading
Simultaneous transfer of cholesterol, triglycerides, and phospholipids to high-density lipoprotein in aging subjects with or without coronary artery disease
Azevedo, Carolina H. M; Wajngarten, Maurício; Prete, Ana C. Lo; Diament, Jayme; Maranhão, Raul C.
Afiliação
  • Azevedo, Carolina H. M; Universidade de São Paulo. São Paulo. BR
  • Wajngarten, Maurício; Universidade de São Paulo. São Paulo. BR
  • Prete, Ana C. Lo; Universidade de São Paulo. São Paulo. BR
  • Diament, Jayme; Universidade de São Paulo. São Paulo. BR
  • Maranhão, Raul C; Universidade de São Paulo. São Paulo. BR
Clinics ; 66(9): 1543-1548, 2011. ilus, tab
Artigo em Inglês | LILACS | ID: lil-604290
Biblioteca responsável: BR1.1
ABSTRACT

OBJECTIVE:

To verify whether the capacity of high-density lipoprotein (HDL) to simultaneously receive nonesterified cholesterol, triglycerides, cholesteryl esters, and phospholipids changes with aging and the presence of coronary artery disease.

DESIGN:

Cross-sectional study with biochemical analyses.

SUBJECTS:

Eleven elderly patients with coronary artery disease (74±5 years) were compared with the following groups of non-coronary artery disease subjects (referred to as "healthy") 25 young (25±5 years), 25 middle-aged (42± years), and 25 elderly subjects (75±8 years).

METHODS:

Plasma samples were incubated with a nanoemulsion labeled with radioactive lipids; the transfer of the lipids from the nanoemulsion to the HDL was measured in chemically precipitated HDL. HDL size and paraoxonase-1 activity were also determined.

RESULTS:

The transfer of cholesteryl esters and phospholipids to high-density lipoprotein was significantly greater (p<0.001) in healthy elderly subjects than in the middle-aged and younger subjects. Non-esterified cholesterol and triglyceride transfer was not different among these three groups. The HDL size was significantly greater (p<0.001) in healthy elderly subjects than in the middle-aged and younger subjects. The paraoxonase-1 activity was similar among the groups. Compared with healthy elderly subjects, coronary artery disease elderly subjects had significantly less (p<0.05) transfer of non-esterified cholesterol, triglycerides, and cholesteryl esters to the HDL and a significantly smaller (p<0.05) HDL size.

CONCLUSION:

Because lipid transfer is enhanced in healthy elderly subjects but not in those with coronary artery disease, increasing lipid transfer to HDL may be a protective mechanism against the disease.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Fosfolipídeos / Triglicerídeos / Doença da Artéria Coronariana / Envelhecimento / Ésteres do Colesterol / HDL-Colesterol Tipo de estudo: Estudo observacional Limite: Adulto / Idoso / Idoso, 80 anos ou mais / Feminino / Humanos / Masculino Idioma: Inglês Revista: Clinics Assunto da revista: Medicina Ano de publicação: 2011 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade de São Paulo/BR

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Fosfolipídeos / Triglicerídeos / Doença da Artéria Coronariana / Envelhecimento / Ésteres do Colesterol / HDL-Colesterol Tipo de estudo: Estudo observacional Limite: Adulto / Idoso / Idoso, 80 anos ou mais / Feminino / Humanos / Masculino Idioma: Inglês Revista: Clinics Assunto da revista: Medicina Ano de publicação: 2011 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade de São Paulo/BR
...