Frequency of human platelet antigens in oncohematological patients with thrombocytopenia and the probability of incompatibility to platelet transfusions
Rev. bras. hematol. hemoter
; 34(3): 202-205, 2012. tab
Artigo
em Inglês
| LILACS
| ID: lil-640868
Biblioteca responsável:
BR408.1
Localização: BR408.1
ABSTRACT
OBJECTIVE:
The objective of this study was to evaluate the frequencies of human platelet antigens in oncohematological patients with thrombocytopenia and to analyze the probability of their incompatibility with platelet transfusions.METHODS:
Platelet antigen genotyping was performed by sequence-specific primer polymerase chain reaction (SSP-PCR) for the HPA-1a, HPA-1b, HPA-2a, HPA-2b, HPA-3a, HPA-3b, HPA-4a, HPA-4b, HPA-5a, HPA-5b; HPA-15a, HPA-15b alleles in 150 patients of the Hematology Service of the Hospital das Clínicas (FMUSP).RESULTS:
The allele frequencies found were HPA-1a 0.837; HPA-1b 0.163; HPA-2a 0.830; HPA-2b 0.170; HPA-3a 0.700; HPA-3b 0.300; HPA-4a 1; HPA-4b 0; HPA-5a 0.887; HPA-5b 0.113; HPA-15a 0.457 and HPA-15b 0.543.CONCLUSIONS:
Data from the present study showed that the A allele is more common in the population than the B allele, except for HPA-15. This suggests that patients homozygous for the B allele are more predisposed to present alloimmunization and refractoriness to platelet transfusions by immune causes. Platelet genotyping could be of great value in the diagnosis of alloimmune thrombocytopenia and to provide compatible platelet concentrates for these patients.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Plaquetas
/
Antígenos de Plaquetas Humanas
/
Transfusão de Plaquetas
Idioma:
Inglês
Revista:
Rev. bras. hematol. hemoter
Assunto da revista:
Hematologia
Ano de publicação:
2012
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Santo Amaro/BR
/
Universidade de São Paulo/BR