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Ocular surface evaluation in patients treated with a fixed combination of prostaglandin analogues with 0.5% timolol maleate topical monotherapy: a randomized clinical trial
Russ, Heloisa Helena; Nogueira-Filho, Pedro Antonio; Barros, Jeison de Nadai; Faria, Nubia Vanessa Lima de; Montiani-Ferreira, Fabiano; Gomes, Jose Alvaro Pereira; Mello, Paulo Augusto Arruda.
Afiliação
  • Russ, Heloisa Helena; Graefe Institute of Ophthalmology. Glaucoma Department. Curitiba. BR
  • Nogueira-Filho, Pedro Antonio; Graefe Institute of Ophthalmology. Glaucoma Department. Curitiba. BR
  • Barros, Jeison de Nadai; Graefe Institute of Ophthalmology. Glaucoma Department. Curitiba. BR
  • Faria, Nubia Vanessa Lima de; Graefe Institute of Ophthalmology. Glaucoma Department. Curitiba. BR
  • Montiani-Ferreira, Fabiano; Graefe Institute of Ophthalmology. Glaucoma Department. Curitiba. BR
  • Gomes, Jose Alvaro Pereira; Graefe Institute of Ophthalmology. Glaucoma Department. Curitiba. BR
  • Mello, Paulo Augusto Arruda; Graefe Institute of Ophthalmology. Glaucoma Department. Curitiba. BR
Clinics ; 68(10): 1318-1324, out. 2013. tab, graf
Artigo em Inglês | LILACS | ID: lil-689986
Biblioteca responsável: BR1.1
ABSTRACT

OBJECTIVES:

To compare ocular surface changes induced via glaucoma treatment in patients using fixed combinations of prostaglandin analogues (travoprost, latanoprost and bimatoprost) with 0.5% timolol maleate

METHODS:

A prospective, multicenter, randomized, parallel group, single-blind clinical trial was performed in 33 patients with ocular hypertension or open angle glaucoma who had not been previously treated. The ocular surface was evaluated prior to and three months after treatment, with a daily drop instillation of one of the three medications. The main outcome measurements included the tear film break-up time, Schirmer's test, Lissamine green staining, the Ocular Surface Disease Index questionnaire, impression cytology using HE and PAS and immunocytochemistry for interleukin-6 and HLA-DR. Ensaiosclinicos.gov.br UTN - U1111-1129-2872

RESULTS:

All of the drugs induced a significant reduction in intraocular pressure. Decreases in the Schirmer's test results were observed with all of the drugs. Decreases in tear-film break-up time were noted with travoprost/timolol and latanoprost/timolol. An increase in the Lissamine green score was noted with travoprost/timolol and bimatoprost/timolol. The Ocular Surface Disease Index score increased after treatment in the travoprost/timolol group. Impression cytology revealed a significant difference in cell-to-cell contact in the same group, an increase in cellularity in all of the groups and an increase in the number of goblet cells in all of the groups. The fixed combinations induced an increase in IL-6 expression in the travoprost/timolol group, in which there was also an increase in HLA-DR expression.

CONCLUSIONS:

All of the fixed combinations induced a significant reduction in intraocular pressure, and the travoprost/timolol group showed increased expression of the inflammatory markers HLA-DR and interleukin-6. All three tested medications resulted in some degree of deterioration in ...
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Prostaglandinas Sintéticas / Timolol / Glaucoma de Ângulo Aberto / Hipertensão Ocular / Olho / Anti-Hipertensivos Tipo de estudo: Ensaio clínico controlado / Estudo observacional / Fatores de risco Limite: Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Clinics Assunto da revista: Medicina Ano de publicação: 2013 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Graefe Institute of Ophthalmology/BR

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Prostaglandinas Sintéticas / Timolol / Glaucoma de Ângulo Aberto / Hipertensão Ocular / Olho / Anti-Hipertensivos Tipo de estudo: Ensaio clínico controlado / Estudo observacional / Fatores de risco Limite: Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Clinics Assunto da revista: Medicina Ano de publicação: 2013 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Graefe Institute of Ophthalmology/BR
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