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The thyroid hormone receptor β-selective agonist GC-1 does not affect tolerance to exercise in hypothyroid rats
Gonçalves, Alexandre; Tolentino, Chineyder Corrêa; Souza, Fernanda Rodrigues de; Huss, Juliana Carla da Costa; Zinato, Karolinne de Lourdes; Lopes, Leandro Teixeira Paranhos; Furlanetto Júnior, Roberto; Neves, Francisco de Assis Rocha.
Afiliação
  • Gonçalves, Alexandre; University of Brasilia. Faculty of Health Sciences. Brasilia. BR
  • Tolentino, Chineyder Corrêa; University of Brasilia. Faculty of Health Sciences. Brasilia. BR
  • Souza, Fernanda Rodrigues de; University of Brasilia. Faculty of Health Sciences. Brasilia. BR
  • Huss, Juliana Carla da Costa; University of Brasilia. Faculty of Health Sciences. Brasilia. BR
  • Zinato, Karolinne de Lourdes; University of Brasilia. Faculty of Health Sciences. Brasilia. BR
  • Lopes, Leandro Teixeira Paranhos; University of Brasilia. Faculty of Health Sciences. Brasilia. BR
  • Furlanetto Júnior, Roberto; University of Brasilia. Faculty of Health Sciences. Brasilia. BR
  • Neves, Francisco de Assis Rocha; University of Brasilia. Faculty of Health Sciences. Brasilia. BR
Arch. endocrinol. metab. (Online) ; 59(2): 141-147, 04/2015. tab, graf
Artigo em Inglês | LILACS | ID: lil-746464
Biblioteca responsável: BR1.1
ABSTRACT
Objective Investigate the effect of GC-1 on tolerance to exercise in rats with experimental hypothyroidism. Materials and methods Hypothyroidism was induced with methimazole sodium and perchlorate treatment. Six groups with eight animals were studied control group (C), hypothyroid group without treatment (HYPO); hypothyroidism treated with physiological doses of tetraiodothyronine (T4) or 10 times higher (10×T4); hypothyroidism treated with equal molar doses of GC-1 (GC-1) or 10 times higher (10×GC-1). After eight weeks, each animal underwent an exercise tolerance test by measuring the time (seconds), in which the rats were swimming with a load attached to their tails without being submerging for more than 10 sec. After the test, the animals were killed, and blood samples were collected for biochemical analysis, and the heart and soleus muscle were removed for weighing and morphometric analysis of the cardiomyocyte. Results Hypothyroidism significantly reduced tolerance to exercise and, treatment with GC-1 1× or T4 in physiological doses recover tolerance test to normal parameters. However, high doses of T4 also decreased tolerance to physical exercise. Conversely, ten times higher doses of GC-1 did not impair tolerance to exercise. Interestingly, hypothyroidism, treated or not with T4 in a physiological range, GC-1 or even high doses of GC-1 (10X) did not change cardiomyocyte diameters and relative weight of the soleus muscle. In contrast, higher doses of T4 significantly increased cardiomyocyte diameter and induced atrophy of the soleus muscle. Conclusion Unlike T4, GC-1 in high doses did not modify tolerance to physical exercise in the rats with hypothyroidism. .
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Fenóis / Tolerância ao Exercício / Receptores beta dos Hormônios Tireóideos / Hipotireoidismo / Acetatos Limite: Animais Idioma: Inglês Revista: Arch. endocrinol. metab. (Online) Assunto da revista: Endocrinologia / Metabolismo Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: University of Brasilia/BR

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Fenóis / Tolerância ao Exercício / Receptores beta dos Hormônios Tireóideos / Hipotireoidismo / Acetatos Limite: Animais Idioma: Inglês Revista: Arch. endocrinol. metab. (Online) Assunto da revista: Endocrinologia / Metabolismo Ano de publicação: 2015 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: University of Brasilia/BR
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